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采用双胃网膜血管化淋巴结转移联合吸脂术分期手术治疗肢体淋巴水肿的前瞻性研究。

Staged surgical treatment of extremity lymphedema with dual gastroepiploic vascularized lymph node transfers followed by suction-assisted lipectomy-A prospective study.

作者信息

Agko Mouchammed, Ciudad Pedro, Chen Hung-Chi

机构信息

Department of Plastic Surgery, China Medical University Hospital, Taichung, Taiwan.

Department of Biological Science and Technology, China Medical University, Taichung, Taiwan.

出版信息

J Surg Oncol. 2018 May;117(6):1148-1156. doi: 10.1002/jso.24969. Epub 2018 Jan 22.

Abstract

BACKGROUND

Both physiologic and excisional procedures have been described for the treatment of lymphedema. However, there exist few reports that combine these procedures. The objective of this study was to evaluate the effectiveness of combining vascularized lymph node transfer (VLNT) with suction-assisted lipectomy (SAL) in a staged manner for the treatment of extremity lymphedema.

METHODS

Patients with unilateral late stage II lymphedema (International Society of Lymphology), who consented to staged surgical treatment, were evaluated prospectively. Between 2014 and 2015, 12 female patients with upper (n = 6) or lower (n = 6) extremity lymphedema completed the treatment protocol. Primary outcomes evaluated included limb size and number of infectious episodes. In addition, compression garment usage was analyzed.

RESULTS

The overall circumference reduction rate was on average 37.9% after VLNT and increased to 96.4% after SAL. While all patients had experienced at least one infectious episode prior to surgical treatment, only one patient did so after VLNT and none after SAL. All patients were able to eventually discontinue compression therapy.

CONCLUSION

VLNT followed by SAL can allow patients with late Stage II lymphedema achieve near normal limb size and eradication of infectious episodes. At follow-up, these desirable outcomes were maintained well after discontinuation of compression therapy.

摘要

背景

已经描述了用于治疗淋巴水肿的生理和切除手术方法。然而,很少有将这些手术方法结合起来的报道。本研究的目的是评估分期联合血管化淋巴结转移(VLNT)与吸脂辅助抽脂术(SAL)治疗肢体淋巴水肿的有效性。

方法

对前瞻性评估的同意接受分期手术治疗的单侧II期晚期淋巴水肿(国际淋巴学会)患者进行研究。2014年至2015年期间,12例上肢(n = 6)或下肢(n = 6)淋巴水肿的女性患者完成了治疗方案。评估的主要结果包括肢体大小和感染发作次数。此外,还分析了压力衣的使用情况。

结果

VLNT后总体周长减少率平均为37.9%,SAL后增加到96.4%。虽然所有患者在手术治疗前至少经历过一次感染发作,但VLNT后只有1例患者出现感染发作,SAL后无患者出现感染发作。所有患者最终都能够停止压力治疗。

结论

先进行VLNT再进行SAL可使II期晚期淋巴水肿患者的肢体大小接近正常,并消除感染发作。在随访中,停止压力治疗后,这些理想的结果得到了很好的维持。

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