Hansson L
J Hypertens Suppl. 1985 Nov;3(2):S65-9.
Assessment of a patient's response to antihypertensive therapy consists of the evaluation of the therapeutic effect in relationship to adverse effects and possible improvement in well-being. The therapeutic effect can be assessed at various levels of aim, such as: (1) a reduction in cardiovascular morbidity and mortality, (2) a normalization of hypertension-induced cardiovascular hypertrophy or renal damage or (3) simply a fall in blood pressure. Adverse effects must also be assessed with various degrees of ambition and, although studies during the initial phases of drug evaluation are of primary importance, there is also the need for chronic surveillance during routine clinical therapy. Finally, the possibility of increased well-being has been raised, in particular in conjunction with angiotensin converting enzyme inhibition therapy. The final assessment of a patient's response to therapy therefore requires that all of these aspects be considered together.
评估患者对抗高血压治疗的反应包括评估治疗效果与不良反应以及生活质量可能改善之间的关系。治疗效果可在不同的目标水平上进行评估，例如：（1）降低心血管发病率和死亡率；（2）使高血压引起的心血管肥厚或肾损害恢复正常；或（3）仅仅是血压下降。不良反应也必须在不同程度的目标下进行评估，尽管在药物评估的初始阶段进行的研究至关重要，但在常规临床治疗期间也需要长期监测。最后，人们提出了提高生活质量的可能性，特别是在联合使用血管紧张素转换酶抑制疗法时。因此，对患者治疗反应的最终评估需要综合考虑所有这些方面。
