Division of Organic Chemistry, CSIR-National Chemical Laboratory , Dr. Homi Bhabha Road, Pune-411008, India.
Academy of Scientific and Innovative Research (AcSIR), New Delhi, India.
Org Lett. 2018 Feb 2;20(3):872-875. doi: 10.1021/acs.orglett.7b04027. Epub 2018 Jan 22.
Ag(I)- or Ag(I)-Au(I)-catalyzed cascade annulation of alkynols (5-hexyn-1-ol systems) with α-ketoesters involving a dual activation process (π and σ) has been developed for the first time. This reaction proceeds through cycloisomerization of alkynol to give the 6-endo-enol ether followed by annulation with an α-ketoester to furnish furo[2,3-b]pyran-2-ones in good yields. Chemical structures of all products were rigorously confirmed by single crystal X-ray analysis and analogy.
Ag(I)-或 Ag(I)-Au(I)-催化的炔丙醇（5-己炔-1-醇体系）与α-酮酸酯的级联环化反应，涉及双活化过程（π 和 σ），这是首次被开发出来的。该反应通过炔丙醇的环异构化生成 6-endo-烯醇醚，然后与α-酮酸酯环化，以高产率得到呋喃[2,3-b]吡喃-2-酮。所有产物的化学结构都通过单晶 X 射线分析和类推得到了严格的证实。
