Parli Sara E, Trivedi Grishma, Woodworth Alison, Chang Phillip K
1 Department of Pharmacy Services, University of Kentucky HealthCare , Lexington, Kentucky.
2 Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy , Lexington, Kentucky.
Surg Infect (Larchmt). 2018 Feb/Mar;19(2):131-136. doi: 10.1089/sur.2017.307. Epub 2018 Jan 22.
Procalcitonin (PCT) is a serum biomarker currently suggested by the Surviving Sepsis Campaign to aid in determination of the appropriate duration of therapy in sepsis patients. We review the use of procalcitonin in patients after trauma or acute care surgery.
A MEDLINE search via PubMed was performed using the combination of "procalcitonin" and "humans" and "injuries, trauma," "wounds and injuries," or "wounds." Studies of burn patients, children, other biomarkers, and non-acute care surgery were excluded.
Procalcitonin may be useful in identifying infection in trauma and post-operative acute care surgery. However, heterogenity exists among patients, and surgery and trauma alone elevate PCT even in the absence of infection.
Although trends in PCT concentrations may offer insight, no standard approach can be recommended currently.
降钙素原（PCT）是一种血清生物标志物，目前脓毒症存活策略建议其有助于确定脓毒症患者的适当治疗时长。我们回顾了降钙素原在创伤或急性护理手术后患者中的应用。
通过PubMed对MEDLINE进行检索，检索词组合为“降钙素原”、“人类”以及“损伤、创伤”、“伤口和损伤”或“伤口”。排除烧伤患者、儿童、其他生物标志物以及非急性护理手术的研究。
降钙素原可能有助于识别创伤和术后急性护理手术中的感染。然而，患者之间存在异质性，并且仅手术和创伤就会使PCT升高，即使没有感染也是如此。
尽管PCT浓度趋势可能提供一定线索，但目前无法推荐标准方法。
