Stefanie Spielman Professor Department of Radiology Wright Center for Innovation in Biomedical Imaging The Ohio State University Biomedical Research Tower BR 720, 460 W 12th Ave Columbus, OH 43210.
Radiology. 2018 Feb;286(2):409-411. doi: 10.1148/radiol.2017172305.
Boehm-Sturm et al ( 1 ) pose a possible paradigm shift in magnetic resonance (MR) imaging: the substitution of iron chelates for gadolinium chelates as paramagnetic contrast agents. The advent of nephrogenic systemic fibrosis challenges the wide-spread perception that gadolinium is benign, and that all gadolinium-based contrast agents (GBCAs) are identical. Long-term gadolinium retention in patients with normal renal function is now a disturbing fact. Unlike gadolinium, iron is an endogenous metal with a tightly regulated transport and storage mechanism. The question the article raises is therefore a compelling one.
Boehm-Sturm 等人（1）提出了磁共振（MR）成像中的一个可能的范式转变：用铁螯合物替代钆螯合物作为顺磁对比剂。肾源性系统性纤维化的出现挑战了人们广泛认为的钆是良性的和所有基于钆的对比剂（GBCA）都是相同的观点。目前，肾功能正常的患者体内长期存在的钆保留是一个令人不安的事实。与钆不同，铁是一种内源性金属，具有严格调控的转运和储存机制。因此，这篇文章提出的问题非常引人注目。
