Department of Medical Sciences, Amedeo di Savoia Hospital, University of Turin, Turin, Italy.
Laboratory of Clinical Biochemistry and Pharmacology, Department of Laboratory Medicine EOLAB, Ente Ospedaliero Cantonale, Bellinzona, Switzerland.
Cancer Chemother Pharmacol. 2018 Mar;81(3):615-620. doi: 10.1007/s00280-018-3520-0. Epub 2018 Jan 22.
Since HCV infection may lead to hepatocellular carcinoma (HCC) and vitamin D (deficiency) is related to cancer, we investigated if SNPs in genes involved in vitamin D pathway could predict HCV-related HCC presence in patients treated with new anti-HCV drugs.
Patients with chronic hepatitis C and treated with direct-acting antivirals were enrolled. SNPs in VDR, CYP27B1, CYP24A1 and GC genes were assessed through real-time PCR. 258 patients were analyzed.
HCC was present in six patients, all taking sofosbuvir, all males and five/six had cirrhosis. HCV-RNA log levels at baseline were statistically different between patients with and without HCC. VDR FokI T > C SNP resulted associated with HCC: all the CC patients were free from HCC. An association between HCC presence and undetectable HCV-RNA at 1 month of therapy was suggested; cirrhosis was related to HCC. HCC risk factors were age, ribavirin administration, IL28Brs12979860CC and previous treatments; VDR FokICC, sex and insulin resistance were protective factors.
These data highlighted vitamin D pathway gene SNPs and HCC relationship in the Italian population; further studies are required.
由于 HCV 感染可能导致肝细胞癌（HCC），而维生素 D（缺乏）与癌症有关，我们研究了维生素 D 途径中涉及的基因中的 SNP 是否可以预测接受新型抗 HCV 药物治疗的患者中与 HCV 相关的 HCC 的存在。
纳入慢性丙型肝炎患者，并接受直接作用抗病毒药物治疗。通过实时 PCR 评估 VDR、CYP27B1、CYP24A1 和 GC 基因中的 SNP。分析了 258 名患者。
六名患者患有 HCC，均接受索非布韦治疗，均为男性，五/六名患者有肝硬化。基线时 HCV-RNA log 水平在有和无 HCC 的患者之间存在统计学差异。VDR FokI T>C SNP 与 HCC 相关：所有 CC 患者均无 HCC。提示 HCC 存在与治疗 1 个月时 HCV-RNA 不可检测之间存在关联；肝硬化与 HCC 有关。HCC 的危险因素是年龄、利巴韦林的使用、IL28Brs12979860CC 和先前的治疗；VDR FokICC、性别和胰岛素抵抗是保护因素。
这些数据强调了意大利人群中维生素 D 途径基因 SNP 与 HCC 之间的关系；需要进一步的研究。
