Department of Physiology, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirao Preto, SP, 14049-900, Brazil.
Curr Hypertens Rep. 2018 Jan 22;20(1):2. doi: 10.1007/s11906-018-0800-3.
Surgical removal of the baroreceptor afferents [sino-aortic denervation (SAD)] leads to a lack of inhibitory feedback to sympathetic outflow, which in turn is expected to result in a large increase in mean arterial pressure (MAP). However, few days after surgery, the sympathetic nerve activity (SNA) and MAP of SAD rats return to a range similar to that observed in control rats. In this review, we present experimental evidence suggesting that breathing contributes to control of SNA and MAP following SAD.The purpose of this review was to discuss studies exploring SNA and MAP regulation in SAD rats, highlighting the possible role of breathing in the neural mechanisms of this modulation of SNA.
Recent studies show that baroreceptor afferent stimulation or removal (SAD) results in changes in the respiratory pattern. Changes in the neural respiratory network and in the respiratory pattern must be considered among mechanisms involved in the modulation of the MAP after SAD.
压力感受器传入纤维（主动脉神经切断术，SAD）的外科切除导致抑制性反馈对交感传出的丧失，这反过来预计会导致平均动脉压（MAP）的大幅增加。然而，手术后几天，SAD 大鼠的交感神经活动（SNA）和 MAP 恢复到类似于对照大鼠的范围。在这篇综述中，我们提出了实验证据表明，呼吸有助于 SAD 后 SNA 和 MAP 的控制。本文综述的目的是讨论探索 SAD 大鼠 SNA 和 MAP 调节的研究，强调呼吸在 SNA 这种调节的神经机制中的可能作用。
最近的研究表明，压力感受器传入刺激或去除（SAD）会导致呼吸模式的变化。在 SAD 后 MAP 调节的机制中，必须考虑神经呼吸网络和呼吸模式的变化。
