Fischer J C, Parker P M, Shaw W W
Microsurgery. 1985;6(4):238-43. doi: 10.1002/micr.1920060410.
Laser Doppler flowmetry (LDF) is a noninvasive, continuous measure of tissue surface microcirculatory red blood cell (RBC) flux. LDF was calibrated against varying RBC volume fractions and flow rates using extracorporeal perfusion of saphenous island flaps of dogs. The RBC flux was found to be linear with LDF signal. The difference in vascular geometry of the skin appeared to play a minor role in generating the LDF signal compared to changes in the RBC flux. In vivo experiments of varying arterial perfusion pressure, flap venous pressure, and total blood flow of the cutaneous island flap had a linear relationship with LDF signal.
激光多普勒血流仪（LDF）是一种对组织表面微循环红细胞（RBC）通量进行无创、连续测量的方法。利用犬隐静脉岛状皮瓣的体外灌注，针对不同的红细胞体积分数和流速对LDF进行了校准。发现红细胞通量与LDF信号呈线性关系。与红细胞通量的变化相比，皮肤血管几何结构的差异在产生LDF信号方面似乎起次要作用。对皮肤岛状皮瓣的动脉灌注压、皮瓣静脉压和总血流量进行变化的体内实验与LDF信号呈线性关系。
