Rif1 蛋白与 G-四链体相互作用控制染色体转录。

Interaction of Rif1 Protein with G-Quadruplex in Control of Chromosome Transactions.

机构信息

Department of Genome Medicine, Tokyo Metropolitan Institute of Medical Science, 2-1-6 Kamikitazawa, Setagaya-ku, Tokyo, 156-8506, Japan.

出版信息

Adv Exp Med Biol. 2017;1042:287-310. doi: 10.1007/978-981-10-6955-0_14.

DOI:10.1007/978-981-10-6955-0_14

PMID:29357064

Abstract

Recent studies on G-quadruplex (G4) revealed crucial and conserved functions of G4 in various biological systems. We recently showed that Rif1, a conserved nuclear factor, binds to G4 present in the intergenic regions and plays a major role in spatiotemporal regulation of DNA replication. Rif1 may tether chromatin fibers through binding to G4, generating specific chromatin domains that dictate the replication timing. G4 and its various binding partners are now implicated in many other chromosome regulations, including transcription, replication initiation, recombination, gene rearrangement, and transposition.

摘要

最近对 G-四链体 (G4) 的研究揭示了 G4 在各种生物系统中的关键和保守功能。我们最近表明，Rif1 是一种保守的核因子，可与基因间区存在的 G4 结合，并在时空上调节 DNA 复制中发挥主要作用。Rif1 可以通过与 G4 结合来固定染色质纤维，形成决定复制时间的特定染色质域。G4 及其各种结合伙伴现在与许多其他染色体调控有关，包括转录、复制起始、重组、基因重排和转座。