Department of Biochemistry and Biophysics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Adv Exp Med Biol. 2017;1042:335-369. doi: 10.1007/978-981-10-6955-0_16.
Successful DNA replication requires intimate coordination with cell-cycle progression. Prior to DNA replication initiation in S phase, a series of essential preparatory events in G phase ensures timely, complete, and precise genome duplication. Among the essential molecular processes are regulated transcriptional upregulation of genes that encode replication proteins, appropriate post-transcriptional control of replication factor abundance and activity, and assembly of DNA-loaded protein complexes to license replication origins. In this chapter we describe these critical G events necessary for DNA replication and their regulation in the context of both cell-cycle entry and cell-cycle progression.
成功的 DNA 复制需要与细胞周期进程密切协调。在 S 期 DNA 复制起始之前，G 期的一系列必要准备事件确保了基因组的及时、完整和精确复制。其中必不可少的分子过程包括：调节复制蛋白编码基因的转录上调、适当的复制因子丰度和活性的转录后控制，以及装载 DNA 的蛋白质复合物的组装以许可复制起点。在本章中，我们将描述这些对于 DNA 复制至关重要的 G 期事件及其在细胞周期进入和细胞周期进程中的调控。
