线粒体替代疗法的进展。
Progress in mitochondrial replacement therapies.
机构信息
Wellcome Centre for Mitochondrial Research, Institute of Genetic Medicine and Institute of Neurosciences, Newcastle University, Newcastle upon Tyne, UK.
出版信息
Nat Rev Mol Cell Biol. 2018 Jan 23;19(2):71-72. doi: 10.1038/nrm.2018.3.
PMID:29358685
Abstract
Mitochondrial DNA is maternally inherited, and pathogenic mutations cause a range of life-limiting conditions. Recent studies indicate that transmission of pathogenic mutations may be prevented by reproductive technologies designed to replace the mitochondria in eggs from affected women.
摘要
线粒体 DNA 通过母系遗传，如果致病性突变会导致一系列危及生命的疾病。最近的研究表明，通过设计的生殖技术，可以替换携带致病性突变的女性卵子中的线粒体，从而防止致病性突变的传递。
Zotero 插件