基于 miRNA、lncRNA 和 mRNA 表达数据构建食管癌特异性 ceRNA 网络。
Construction of an oesophageal cancer-specific ceRNA network based on miRNA, lncRNA, and mRNA expression data.
机构信息
Department of Pharmacy, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
Cancer Centre, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China.
出版信息
World J Gastroenterol. 2018 Jan 7;24(1):23-34. doi: 10.3748/wjg.v24.i1.23.
AIM
To explore the expression profiles of microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and mRNAs in oesophageal squamous cell carcinoma (ESCC) in order to construct an oesophageal cancer-specific competing endogenous RNA (ceRNA) network.
METHODS
In this work, the expression data of miRNAs, lncRNAs, and mRNAs in ESCC were obtained. An oesophageal cancer-specific ceRNA network was then constructed and investigated.
RESULTS
CeRNAs have the ability to reduce the targeting activity of miRNAs, leading to the de-repression of specific mRNAs with common miRNA response elements. CeRNA interactions have a critical effect in gene regulation and cancer development.
CONCLUSION
This study suggests a novel perspective on potential oesophageal cancer mechanisms as well as novel pathways for modulating ceRNA networks for treating cancers.
目的
探讨食管鳞状细胞癌（ESCC）中 microRNAs（miRNAs）、长链非编码 RNA（lncRNAs）和 mRNAs 的表达谱，构建食管癌特异性竞争性内源 RNA（ceRNA）网络。
方法
本研究中，我们获得了 ESCC 中 miRNAs、lncRNAs 和 mRNAs 的表达数据，构建并研究了食管癌特异性 ceRNA 网络。
结果
ceRNAs 具有降低 miRNAs 靶向活性的能力，导致具有共同 miRNA 反应元件的特定 mRNAs 去抑制。ceRNA 相互作用对基因调控和癌症发生具有关键作用。
结论
本研究为潜在的食管癌机制以及调控 ceRNA 网络治疗癌症的新途径提供了新的视角。
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