de Laffolie Jan, Laass Martin W, Scholz Dietmar, Zimmer Klaus-Peter, Buderus Stephan
General Pediatrics & Neonatology, Justus-Liebig-University, Giessen, Germany.
Department of Pediatrics, Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
Gastroenterol Res Pract. 2017;2017:8424628. doi: 10.1155/2017/8424628. Epub 2017 Dec 5.
To determine the prevalence of anemia and its association with disease severity in children and adolescents with IBD.
CEDATA-GPGE is a registry for pediatric patients with IBD in Germany and Austria from 90 specialized centers. As markers of disease severity, analysis included patient self-assessment on a Likert scale (1-5; 1 = very good) and physicians' general assessment (0 = no activity to 4 = severe disease) and the disease indices. Anemia was defined as hemoglobin concentration below the 3rd percentile.
Prevalence of anemia was 65.2% in CD and 60.2% in UC. Anemic CD and UC patients showed significantly worse self-assessment than patients without anemia (average ± standard deviation; CD: 3.0 ± 0.9 versus 2.5 ± 0.9, < 0.0001; UC: 2.9 ± 0.9 versus 2.3 ± 0.9, < 0.0001). Accordingly, physicians' general assessment (PGA) was significantly worse in anemic than in nonanemic patients in CD ( < 0.0001) and UC ( < 0.0001). PCDAI in anemic CD, < 0.0001, and PUCAI in anemic UC patients, < 0.0001, were significantly higher than in nonanemic patients. 40.0% of anemic CD and 47.8% of anemic UC patients received iron during follow-up.
Almost 2/3 of pediatric IBD patients are anemic. Patients' self-assessment and disease severity as determined by PGA and activity indices are worse in anemic patients. Contrastingly, only a minority received iron therapy.
确定炎症性肠病（IBD）儿童和青少年贫血的患病率及其与疾病严重程度的关联。
CEDATA - GPGE是德国和奥地利90个专业中心的IBD儿科患者登记处。作为疾病严重程度的指标，分析包括患者基于李克特量表（1 - 5；1 = 非常好）的自我评估、医生的总体评估（0 = 无活动至4 = 严重疾病）以及疾病指数。贫血定义为血红蛋白浓度低于第3百分位数。
克罗恩病（CD）患者贫血患病率为65.2%，溃疡性结肠炎（UC）患者为60.2%。贫血的CD和UC患者自我评估明显比无贫血患者差（平均值±标准差；CD：3.0±0.9对2.5±0.9，P < 0.0001；UC：2.9±0.9对2.3±0.9，P < 0.0001）。相应地，贫血患者的医生总体评估（PGA）在CD（P < 0.0001）和UC（P < 0.0001）中明显比非贫血患者差。贫血CD患者的儿科克罗恩病活动指数（PCDAI），P < 0.0001，贫血UC患者的儿科溃疡性结肠炎活动指数（PUCAI），P < 0.0001，明显高于非贫血患者。40.0%的贫血CD患者和47.8%的贫血UC患者在随访期间接受了铁剂治疗。
近三分之二的儿科IBD患者贫血。贫血患者的自我评估以及由PGA和活动指数确定的疾病严重程度更差。相比之下，只有少数患者接受了铁剂治疗。
