Kumari Kamlesh, Sahni Neeru, Kumari Vimla, Saini Vikas
Department of Anaesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Gynaecology and Obstetric, Dr. S.N. Medical College Jodhpur, Rajasthan, India.
Turk J Anaesthesiol Reanim. 2017 Dec;45(6):377-379. doi: 10.5152/TJAR.2017.74508. Epub 2017 Sep 15.
Anti-N-methyl-D-aspartate (NMDA) receptor encephalitis is an immune-mediated disease commonly associated with ovarian teratoma. Anti-NMDA-receptor autoantibodies disrupt NMDA function leading to the development of psychosis, seizures and autonomic dysfunction. The treatment includes underlying tumour resection and immunosuppression. Slow recovery and unpredictable clinical course makes intensive care management of these patients challenging. We report the management of two young female patients with anti-NMDA-receptor encephalitis associated with ovarian teratoma.
抗N-甲基-D-天冬氨酸(NMDA)受体脑炎是一种通常与卵巢畸胎瘤相关的免疫介导性疾病。抗NMDA受体自身抗体破坏NMDA功能,导致精神病、癫痫发作和自主神经功能障碍的发生。治疗包括切除潜在肿瘤和免疫抑制。恢复缓慢且临床病程不可预测,使得对这些患者的重症监护管理具有挑战性。我们报告了两名患有与卵巢畸胎瘤相关的抗NMDA受体脑炎的年轻女性患者的治疗情况。