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抗N-甲基-D-天冬氨酸受体(NMDA)脑炎:一种罕见的、自身免疫介导的脑炎形式。

Anti-NMDA encephalitis: an uncommon, autoimmune mediated form of encephalitis.

作者信息

Azizyan Avetis, Albrektson Joshua R, Maya Marcel M, Pressman Barry D, Moser Franklin

机构信息

Department of Radiology, Cedars Sinai Hospital, Los Angeles, USA.

出版信息

J Radiol Case Rep. 2014 Aug 31;8(8):1-6. doi: 10.3941/jrcr.v8i8.1566. eCollection 2014 Aug.

DOI:10.3941/jrcr.v8i8.1566
PMID:25426239
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4242142/
Abstract

We report an interesting case of a 19 year old female with findings on MRI suggestive of viral encephalitis. An extensive workup was negative for infectious causes and she was subsequently diagnosed with anti-NMDA encephalitis. Anti-NMDA encephalitis is a highly lethal but treatable form of autoimmune encephalitis that has recently been characterized. It is frequently found in young women and associated with an underlying teratoma. Although rare, this diagnosis should be considered in young females for whom a rapid onset of encephalitis cannot be explained by more common causes.

摘要

我们报告了一例有趣的病例,一名19岁女性,其MRI检查结果提示为病毒性脑炎。全面检查未发现感染性病因,随后她被诊断为抗N-甲基-D-天冬氨酸(NMDA)受体脑炎。抗NMDA受体脑炎是一种新近被明确的自身免疫性脑炎,极具致死性但可治疗。它常见于年轻女性,且与潜在的畸胎瘤相关。尽管罕见,但对于那些脑炎快速起病无法用更常见病因解释的年轻女性,应考虑这一诊断。

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本文引用的文献

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Causes of encephalitis and differences in their clinical presentations in England: a multicentre, population-based prospective study.脑炎的病因及其在英国的临床表现差异:一项多中心、基于人群的前瞻性研究。
Lancet Infect Dis. 2010 Dec;10(12):835-44. doi: 10.1016/S1473-3099(10)70222-X. Epub 2010 Oct 15.
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Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis.抗 NMDA 受体脑炎的细胞和突触机制。
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Evidence for antibody-mediated pathogenesis in anti-NMDAR encephalitis associated with ovarian teratoma.抗 NMDAR 脑炎伴卵巢畸胎瘤中抗体介导发病机制的证据。
Acta Neuropathol. 2009 Dec;118(6):737-43. doi: 10.1007/s00401-009-0582-4.
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Response of anti-NMDA receptor encephalitis without tumor to immunotherapy including rituximab.无肿瘤的抗N-甲基-D-天冬氨酸受体脑炎对包括利妥昔单抗在内的免疫疗法的反应
Neurology. 2008 Dec 2;71(23):1921-3. doi: 10.1212/01.wnl.0000336648.43562.59.
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Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies.抗N-甲基-D-天冬氨酸受体脑炎:病例系列及抗体作用分析
Lancet Neurol. 2008 Dec;7(12):1091-8. doi: 10.1016/S1474-4422(08)70224-2. Epub 2008 Oct 11.
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Neurological response to early removal of ovarian teratoma in anti-NMDAR encephalitis.抗N-甲基-D-天冬氨酸受体(NMDAR)脑炎中早期切除卵巢畸胎瘤后的神经学反应
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Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal.日本的抗N-甲基-D-天冬氨酸受体脑炎:未切除肿瘤的长期预后
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Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma.与卵巢畸胎瘤相关的副肿瘤性抗N-甲基-D-天冬氨酸受体脑炎
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Paraneoplastic limbic encephalitis: neurological symptoms, immunological findings and tumour association in 50 patients.副肿瘤性边缘叶脑炎:50例患者的神经症状、免疫学发现及肿瘤关联
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