Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders.
作者信息
Walter Jonas, Nickels Sarah Louise, Schwamborn Jens Christian
机构信息
Braingineering Technologies SARL, Esch-sur-Alzette, Luxembourg.
University of Luxembourg, Luxembourg Centre for Systems Biomedicine, Belvaux, Luxembourg.
出版信息
Stem Cell Investig. 2017 Dec 28;4:101. doi: 10.21037/sci.2017.11.08. eCollection 2017.
Abstract
摘要
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Human induced pluripotent stem cell-derived neuronal progenitors are a suitable and effective drug discovery model for neurological mtDNA disorders.人诱导多能干细胞衍生的神经祖细胞是用于神经线粒体DNA疾病的合适且有效的药物发现模型。
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本文引用的文献
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Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.人诱导多能干细胞衍生的神经祖细胞是一种有效的神经 mtDNA 疾病药物发现模型。
Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.
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Moving stem cells to the clinic: potential and limitations for brain repair.将干细胞应用于临床：脑修复的潜力与局限
Neuron. 2015 Apr 8;86(1):187-206. doi: 10.1016/j.neuron.2015.03.002.
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The neural stem cell fate determinant TRIM32 regulates complex behavioral traits.神经干细胞命运决定因子TRIM32调控复杂行为特征。
Front Cell Neurosci. 2015 Mar 18;9:75. doi: 10.3389/fncel.2015.00075. eCollection 2015.
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Mitochondrial DNA: impacting central and peripheral nervous systems.线粒体DNA：影响中枢和外周神经系统
Neuron. 2014 Dec 17;84(6):1126-42. doi: 10.1016/j.neuron.2014.11.022.
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Neural stem cells in Parkinson's disease: a role for neurogenesis defects in onset and progression.帕金森病中的神经干细胞：神经发生缺陷在发病和进展中的作用。
Cell Mol Life Sci. 2015 Feb;72(4):773-97. doi: 10.1007/s00018-014-1774-1. Epub 2014 Nov 18.
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Mitochondrial regulation in pluripotent stem cells.多能干细胞中的线粒体调控。
Cell Metab. 2013 Sep 3;18(3):325-32. doi: 10.1016/j.cmet.2013.06.005. Epub 2013 Jul 11.
7
The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis.线粒体基因组：将线粒体 DNA 整合到细胞内稳态中。
Cold Spring Harb Perspect Biol. 2013 May 1;5(5):a011080. doi: 10.1101/cshperspect.a011080.
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Derivation and expansion using only small molecules of human neural progenitors for neurodegenerative disease modeling.使用小分子仅从人类神经祖细胞中衍生和扩增用于神经退行性疾病建模。
PLoS One. 2013;8(3):e59252. doi: 10.1371/journal.pone.0059252. Epub 2013 Mar 22.
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Genetic correction of a LRRK2 mutation in human iPSCs links parkinsonian neurodegeneration to ERK-dependent changes in gene expression.基因校正人类诱导多能干细胞中的 LRRK2 突变将帕金森病神经退行性变与 ERK 依赖性基因表达变化联系起来。
Cell Stem Cell. 2013 Mar 7;12(3):354-67. doi: 10.1016/j.stem.2013.01.008.
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Modeling human cortical development in vitro using induced pluripotent stem cells.利用诱导多能干细胞体外模拟人类皮质发育。
Proc Natl Acad Sci U S A. 2012 Jul 31;109(31):12770-5. doi: 10.1073/pnas.1202944109. Epub 2012 Jul 3.
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