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[一种鼠疫单克隆抗体红细胞诊断试剂的试验结果]

[Results of a trial of a plague monoclonal antibody erythrocyte diagnostic agent].

作者信息

Sergiev V P, Fedorov Iu M, Levi M I, Kanatov Iu V

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1985 Nov(11):82-7.

PMID:2936047
Abstract

Plague antibody monoclonal erythrocyte diagnosticum was studied in serological tests simultaneously with commercial plague antibody erythrocyte diagnosticum prepared on the basis of hyperimmune horse serum and with commercial plague antigenic erythrocyte diagnosticum. In this investigation the suspensions of numerous strains of Yersinia pestis, other closely related and heterologous organisms, experimentally infected wild and laboratory animals, as well as samples of materials obtained from small rodents caught in several natural foci of plague, were studied. The monoclonal diagnosticum was, practically, not inferior to the similar commercial preparation with respect to the frequency of positive results and the activity of the materials under study in serological tests, but showed greater specificity, as it reacted strictly with Y. pestis capsular antigen.

摘要

对鼠疫抗体单克隆红细胞诊断制剂进行了血清学检测研究,并与基于超免疫马血清制备的市售鼠疫抗体红细胞诊断制剂以及市售鼠疫抗原红细胞诊断制剂同时进行了比较。在这项研究中,对众多鼠疫耶尔森菌菌株、其他密切相关和异源生物的悬液、经实验感染的野生和实验动物,以及从几个鼠疫自然疫源地捕获的小型啮齿动物身上采集的材料样本进行了研究。在血清学检测中,就阳性结果的频率和所研究材料的活性而言,单克隆诊断制剂实际上并不亚于类似的市售制剂,但显示出更高的特异性,因为它仅与鼠疫耶尔森菌荚膜抗原发生反应。

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