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Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy.

作者信息

Dispenza Melanie C, Pongracic Jacqueline A, Singh Anne M, Bochner Bruce S

机构信息

Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.

Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Allergy/Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill.

出版信息

J Allergy Clin Immunol. 2018 May;141(5):1914-1916.e7. doi: 10.1016/j.jaci.2017.12.987. Epub 2018 Jan 31.

DOI:10.1016/j.jaci.2017.12.987
PMID:29360526
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7297295/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51e/7297295/a1bdf67eaa5a/nihms-1596617-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51e/7297295/685bb1f23832/nihms-1596617-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51e/7297295/a1bdf67eaa5a/nihms-1596617-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51e/7297295/685bb1f23832/nihms-1596617-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e51e/7297295/a1bdf67eaa5a/nihms-1596617-f0002.jpg

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本文引用的文献

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2
Combining anti-IgE with oral immunotherapy.将抗IgE与口服免疫疗法相结合。
Pediatr Allergy Immunol. 2017 Nov;28(7):619-627. doi: 10.1111/pai.12767. Epub 2017 Sep 7.
3
Ibrutinib, a Bruton's tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity.依鲁替尼是一种用于治疗淋巴增殖性疾病的布鲁顿酪氨酸激酶抑制剂，它能消除气源性变应原皮肤试验和嗜碱性粒细胞活化试验的反应性。
J Allergy Clin Immunol. 2017 Sep;140(3):875-879.e1. doi: 10.1016/j.jaci.2017.03.013. Epub 2017 Apr 4.
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Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis.嗜碱性粒细胞、高亲和力IgE受体与人类过敏反应中的CCL2
J Allergy Clin Immunol. 2017 Sep;140(3):750-758.e15. doi: 10.1016/j.jaci.2016.12.989. Epub 2017 Mar 22.
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Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.布鲁顿酪氨酸激酶抑制剂伊布替尼（PCI-32765）在复发/难治性 B 细胞恶性肿瘤患者中具有显著的活性。
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