Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy.
作者信息
Dispenza Melanie C, Pongracic Jacqueline A, Singh Anne M, Bochner Bruce S
机构信息
Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill.
Department of Medicine, Division of Allergy and Immunology, Northwestern University Feinberg School of Medicine, Chicago, Ill; Ann and Robert H. Lurie Children's Hospital of Chicago, Division of Allergy/Immunology, Department of Pediatrics, Northwestern University Feinberg School of Medicine, Chicago, Ill.
出版信息
J Allergy Clin Immunol. 2018 May;141(5):1914-1916.e7. doi: 10.1016/j.jaci.2017.12.987. Epub 2018 Jan 31.
Abstract
摘要
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Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy.短期依鲁替尼治疗可抑制花生或坚果过敏成人的皮肤试验反应，并消除IgE介导的嗜碱性粒细胞活化。
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本文引用的文献
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Potential applications of Bruton's tyrosine kinase inhibitors for the prevention of allergic reactions.布鲁顿酪氨酸激酶抑制剂在预防过敏反应方面的潜在应用。
Expert Rev Clin Immunol. 2017 Oct;13(10):921-923. doi: 10.1080/1744666X.2017.1370374. Epub 2017 Aug 31.
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Combining anti-IgE with oral immunotherapy.将抗IgE与口服免疫疗法相结合。
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3
Ibrutinib, a Bruton's tyrosine kinase inhibitor used for treatment of lymphoproliferative disorders, eliminates both aeroallergen skin test and basophil activation test reactivity.依鲁替尼是一种用于治疗淋巴增殖性疾病的布鲁顿酪氨酸激酶抑制剂，它能消除气源性变应原皮肤试验和嗜碱性粒细胞活化试验的反应性。
J Allergy Clin Immunol. 2017 Sep;140(3):875-879.e1. doi: 10.1016/j.jaci.2017.03.013. Epub 2017 Apr 4.
4
Basophils, high-affinity IgE receptors, and CCL2 in human anaphylaxis.嗜碱性粒细胞、高亲和力IgE受体与人类过敏反应中的CCL2
J Allergy Clin Immunol. 2017 Sep;140(3):750-758.e15. doi: 10.1016/j.jaci.2016.12.989. Epub 2017 Mar 22.
5
Bruton tyrosine kinase inhibitor ibrutinib (PCI-32765) has significant activity in patients with relapsed/refractory B-cell malignancies.布鲁顿酪氨酸激酶抑制剂伊布替尼（PCI-32765）在复发/难治性 B 细胞恶性肿瘤患者中具有显著的活性。
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6
Inhibition of IgE-mediated secretion from human basophils with a highly selective Bruton's tyrosine kinase, Btk, inhibitor.高选择性布鲁顿酪氨酸激酶（BTK）抑制剂抑制人嗜碱性粒细胞 IgE 介导的分泌。
Int Immunopharmacol. 2011 Apr;11(4):475-9. doi: 10.1016/j.intimp.2010.12.018. Epub 2011 Jan 14.
7
Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses.Tec 家族激酶缺失——白细胞介素-2 诱导的 T 细胞激酶（Itk）和布鲁顿酪氨酸激酶（Btk）——严重损害了 FcεRI 依赖性肥大细胞反应。
J Biol Chem. 2011 Mar 18;286(11):9503-13. doi: 10.1074/jbc.M110.165613. Epub 2011 Jan 6.
8
The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated mast cells.在抗原刺激的肥大细胞中，Btk的磷酸肌醇3激酶依赖性激活对于最佳类花生酸生成和活性氧的产生是必需的。
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A double-blind, single-dose, crossover comparison of cetirizine, terfenadine, loratadine, astemizole, and chlorpheniramine versus placebo: suppressive effects on histamine-induced wheals and flares during 24 hours in normal subjects.西替利嗪、特非那定、氯雷他定、阿司咪唑和氯苯那敏与安慰剂的双盲、单剂量、交叉对照比较：对正常受试者24小时内组胺诱发风团和潮红的抑制作用
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