Phukan Rup Kumar, Borkakoty Biswa Jyoti, Phukan Sanjib Kumar, Bhandari Kumar, Mahanta Jagdish, Tawsik Sopai, Bhandari Sangita, Rai Ashish, Narain Kanwar
ICMR - Regional Medical Research Centre (RMRC), N.E. Region, Post Box No. 105, Dibrugarh, 786 001, Assam, India.
Department of Health Care, Health Service and Family Welfare, Govt. of Sikkim, Sikkim, India.
Cancer Epidemiol. 2018 Apr;53:35-41. doi: 10.1016/j.canep.2018.01.005. Epub 2018 Jan 19.
Dietary factors, tobacco, and alcohol use have been identified as important factors of rising various cancer incidence in several northeastern states of India. However, little is known about the factors associated with hepatocellular carcinoma (HCC) in this region. The aim of the paper was to identify the factors associated with HCC in the northeast region.
A case-control study was conducted in Arunachal Pradesh and Sikkim, two northeastern states of India, including 104 histologically-confirmed cases of HCC and same number (104) of age and sex matched control enrolled. Logistic regression analysis was performed to identify the factors associated with HCC.
A statistically significant association was demonstrated between HCC and alcohol consumption, consumption of 'Sai-mod' (OR 2.77, CI 1.57-4.87) a homemade alcohol beverage, and with HBV (OR 7.97, CI 3.36-18.94). Positive synergism index (S = 3.04) was observed between HBV and alcohol consumption to risk of HCC. Higher intake of processed meat (OR 2.56, CI 1.09-6.03) and processed fish (OR 2.24, CI 1.02-4.95) were found associated with increased risk of HCC; and decreased risk of HCC with fresh fish, fruits, and milk.
Strong relationship between different dietary factors, alcohol beverage with HCC suggests that control on dietary and drinking habit will be an important strategy to combat HCC in this region. Risk factors identified in this study will help to plan more effectively targeted risk reduction strategies and programs in this region.
饮食因素、烟草和酒精使用已被确定为印度东北部几个邦各种癌症发病率上升的重要因素。然而，关于该地区肝细胞癌（HCC）相关因素的了解却很少。本文的目的是确定东北地区与HCC相关的因素。
在印度东北部的两个邦阿鲁纳恰尔邦和锡金邦进行了一项病例对照研究，纳入了104例经组织学确诊的HCC病例以及相同数量（104例）年龄和性别匹配的对照。进行逻辑回归分析以确定与HCC相关的因素。
HCC与饮酒、饮用自制酒精饮料“赛莫德”（比值比[OR]2.77，可信区间[CI]1.57 - 4.87）以及乙肝病毒（HBV）（OR 7.97，CI 3.36 - 18.94）之间存在统计学显著关联。观察到HBV与饮酒对HCC风险的正协同指数（S = 3.04）。发现加工肉类摄入量较高（OR 2.56，CI 1.09 - 6.03）和加工鱼类摄入量较高（OR 2.24，CI 1.02 - 4.95）与HCC风险增加相关；而食用新鲜鱼类、水果和牛奶则降低HCC风险。
不同饮食因素、酒精饮料与HCC之间的密切关系表明，控制饮食习惯和饮酒习惯将是该地区对抗HCC的重要策略。本研究确定的风险因素将有助于更有效地规划该地区针对性的风险降低策略和项目。
