起死回生：肿瘤浸润淋巴细胞凋亡与肿瘤免疫逃逸 - Suppr

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超能文献

Back from the dead: TIL apoptosis in cancer immune evasion.

作者信息

Horton Brendan L, Gajewski Thomas F

机构信息

Department of Pathology, University of Chicago, Chicago, IL, USA.

出版信息

Br J Cancer. 2018 Feb 6;118(3):309-311. doi: 10.1038/bjc.2017.483. Epub 2018 Jan 23.

DOI:10.1038/bjc.2017.483

PMID:29360810

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5808044/

Abstract

摘要

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Back from the dead: TIL apoptosis in cancer immune evasion.起死回生：肿瘤浸润淋巴细胞凋亡与肿瘤免疫逃逸

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CD8+ tumor-infiltrating lymphocytes are primed for Fas-mediated activation-induced cell death but are not apoptotic in situ.CD8 +肿瘤浸润淋巴细胞已准备好进行Fas介导的激活诱导的细胞死亡，但在原位并未凋亡。

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Signaling abnormalities, apoptosis, and reduced proliferation of circulating and tumor-infiltrating lymphocytes in patients with oral carcinoma.口腔癌患者循环及肿瘤浸润淋巴细胞的信号异常、凋亡及增殖减少。

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Infiltration of tumor-reactive transforming growth factor-beta insensitive CD8+ T cells into the tumor parenchyma is associated with apoptosis and rejection of tumor cells.肿瘤反应性转化生长因子-β不敏感的CD8 + T细胞浸润到肿瘤实质中与肿瘤细胞的凋亡和排斥有关。

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Expression of MG7-Ag in patients with gastric cancer correlates with weaker T cell immune response and more proinflammatory cytokine secretion.胃癌患者中MG7抗原的表达与较弱的T细胞免疫反应及更多促炎细胞因子分泌相关。

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本文引用的文献

Resistance to cancer immunotherapy mediated by apoptosis of tumor-infiltrating lymphocytes.肿瘤浸润淋巴细胞凋亡介导的癌症免疫治疗抵抗。

Nat Commun. 2017 Nov 10;8(1):1404. doi: 10.1038/s41467-017-00784-1.

Intratumoral CD8 T-cell Apoptosis Is a Major Component of T-cell Dysfunction and Impedes Antitumor Immunity.肿瘤内 CD8 T 细胞凋亡是 T 细胞功能障碍的主要组成部分，并阻碍抗肿瘤免疫。

Cancer Immunol Res. 2018 Jan;6(1):14-24. doi: 10.1158/2326-6066.CIR-17-0249. Epub 2017 Nov 2.

The EGR2 targets LAG-3 and 4-1BB describe and regulate dysfunctional antigen-specific CD8+ T cells in the tumor microenvironment.EGR2靶向LAG-3和4-1BB描述并调节肿瘤微环境中功能失调的抗原特异性CD8 + T细胞。

J Exp Med. 2017 Feb;214(2):381-400. doi: 10.1084/jem.20160485. Epub 2017 Jan 23.

Density of immunogenic antigens does not explain the presence or absence of the T-cell-inflamed tumor microenvironment in melanoma.免疫原性抗原的密度并不能解释黑色素瘤中T细胞炎症性肿瘤微环境的存在与否。

Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7759-E7768. doi: 10.1073/pnas.1609376113. Epub 2016 Nov 11.

Tumor immune profiling predicts response to anti-PD-1 therapy in human melanoma.肿瘤免疫谱分析可预测人类黑色素瘤对抗PD-1治疗的反应。

J Clin Invest. 2016 Sep 1;126(9):3447-52. doi: 10.1172/JCI87324. Epub 2016 Aug 15.

Innate and adaptive immune cells in the tumor microenvironment.肿瘤微环境中的固有和适应性免疫细胞。

Nat Immunol. 2013 Oct;14(10):1014-22. doi: 10.1038/ni.2703.

Human melanoma-specific CD8(+) T-cells from metastases are capable of antigen-specific degranulation and cytolysis directly ex vivo.转移性黑色素瘤患者的特异性 CD8(+) T 细胞能够直接在体外进行抗原特异性脱颗粒和细胞溶解。

Oncoimmunology. 2012 Jul 1;1(4):467-530. doi: 10.4161/onci.19856.

Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.抗 PD-1 抗体在癌症中的安全性、活性和免疫相关性。

N Engl J Med. 2012 Jun 28;366(26):2443-54. doi: 10.1056/NEJMoa1200690. Epub 2012 Jun 2.

Improved survival with ipilimumab in patients with metastatic melanoma.Ipilimumab 改善转移性黑色素瘤患者的生存。

N Engl J Med. 2010 Aug 19;363(8):711-23. doi: 10.1056/NEJMoa1003466. Epub 2010 Jun 5.

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