Tada M, Kuzuya T
Adv Prostaglandin Thromboxane Leukot Res. 1985;15:481-4.
This chapter documents the significance of TXA2 and PGI2 in the pathologic events associated with active coronary artery disease. We suggest that altered metabolism of these prostanoids may result in disintegration of platelet and vascular wall reactivities accompanying coronary spasm or intravascular thrombosis associated with myocardial cell necrosis. Further studies should be carried out to determine if coronary circulatory disorders and subsequent myocardial cell injury can be affected by disintegration of the lipoxygenase system that plays a pivotal role in maintaining homeostasis in vascular endothelium and blood components.
本章记录了血栓素A2（TXA2）和前列环素（PGI2）在与活动性冠状动脉疾病相关的病理事件中的重要性。我们认为，这些前列腺素代谢的改变可能导致伴随冠状动脉痉挛或与心肌细胞坏死相关的血管内血栓形成的血小板和血管壁反应性的瓦解。应开展进一步研究，以确定在维持血管内皮和血液成分内稳态中起关键作用的脂氧合酶系统的瓦解是否会影响冠状动脉循环障碍及随后的心肌细胞损伤。
