肌肉骨骼疾病的预后、预防和治疗的双胞胎研究。
Twin studies for the prognosis, prevention and treatment of musculoskeletal conditions.
机构信息
The University of Melbourne, Melbourne School of Population and Global Health, Centre for Epidemiology and Biostatistics, Melbourne, Victoria, Australia.
Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Diamantina, MG, Brazil.
出版信息
Braz J Phys Ther. 2018 May-Jun;22(3):184-189. doi: 10.1016/j.bjpt.2017.12.004. Epub 2017 Dec 27.
BACKGROUND
Musculoskeletal conditions are highly prevalent in our ageing society and are therefore incurring substantial increases in population levels of years lived with disability (YLD). An evidence-based approach to the prognosis, prevention, and treatment of those disorders can allow an overall improvement in the quality of life of patients, while also softening the burden on national health care systems.
METHODS
In this Masterclass article, we provide an overview of the most relevant twin study designs, their advantages, limitations and major contributions to the investigation of traits related to the domain of musculoskeletal physical therapy.
CONCLUSIONS
Twin studies can be an important scientific tool to address issues related to musculoskeletal conditions. They allow researchers to understand how genes and environment combine to influence human health and disease. Twin registries and international collaboration through existing networks can provide resources for achieving large sample sizes and access to expertise in study design and analysis of twin data.
背景
肌肉骨骼疾病在老龄化社会中普遍高发，因此导致残疾调整生命年（YLD）的人群水平显著增加。对这些疾病的预后、预防和治疗采取循证方法可以整体提高患者的生活质量，同时减轻国家卫生保健系统的负担。
方法
在这篇大师班文章中，我们概述了最相关的双胞胎研究设计，以及它们在研究与肌肉骨骼物理治疗领域相关特征方面的优势、局限性和主要贡献。
结论
双胞胎研究可以成为解决肌肉骨骼疾病相关问题的重要科学工具。它们使研究人员能够了解基因和环境如何共同影响人类健康和疾病。双胞胎登记处和通过现有网络进行的国际合作可以提供资源，以实现大样本量并获得在双胞胎数据研究设计和分析方面的专业知识。
Zotero 插件