Programa de Pós-Graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
Musculoskeletal Health Research Group, Faculty of Health Sciences, The University of Sydney, PO Box 170, Lidcombe, Sydney, 1825, Australia.
Eur Spine J. 2019 Feb;28(2):224-233. doi: 10.1007/s00586-018-5850-3. Epub 2018 Dec 6.
To investigate associations between anthropometric measures (birthweight, weight gain and current BMI) and back pain; and to determine whether these associations differ between those born with low or full birthweight.
The cross-sectional associations between the lifetime prevalence of back pain and anthropometric measures (birthweight, weight gain and current BMI) among 2754 adult twins were investigated in three stages: total sample; within-pair case-control for monozygotic and dizygotic twins together; and within-pair case-control analysis separated by dizygotic and monozygotic. Results were expressed as odds ratios (OR) and 95% confidence intervals (CI).
Birthweight was not associated with back pain (OR 0.99; 95% CI 0.99-1.00), but a weak association was found between weight gain (OR 1.01; CI 1.00-1.01) or current BMI (OR 1.02; 95% CI 1.00-1.05) and back pain in the total sample analysis. These associations did not remain significant after adjusting for genetics. The associations did not differ between those whose were born with low or full birthweight.
Birthweight was not associated with prevalence of back pain in adulthood. Weight gain and current BMI were weakly associated with back pain prevalence in the total sample analysis but did not differ between those born with low or full birthweight. However, the small-magnitude association only just achieved significance and appeared to be confounded by genetics and the early shared environment. Our results suggest that a direct link between these predictors and back pain in adults is unlikely. These slides can be retrieved under Electronic Supplementary Material.
研究人体测量学指标（出生体重、体重增加和当前 BMI）与背痛之间的关联，并确定这些关联在低出生体重儿和足月儿之间是否存在差异。
在三个阶段研究了 2754 对成年双胞胎一生中背痛的终生患病率与人体测量学指标（出生体重、体重增加和当前 BMI）之间的横断面关联：总样本；单卵双胞胎和双卵双胞胎的配对病例对照；以及双卵双胞胎和单卵双胞胎分开的配对病例对照分析。结果表示为比值比（OR）和 95%置信区间（CI）。
出生体重与背痛无关（OR 0.99；95%CI 0.99-1.00），但体重增加（OR 1.01；CI 1.00-1.01）或当前 BMI（OR 1.02；95%CI 1.00-1.05）与总样本分析中的背痛呈弱相关。在调整遗传因素后，这些关联不再显著。这些关联在低出生体重儿和足月儿之间没有差异。
出生体重与成年人背痛的患病率无关。体重增加和当前 BMI 与总样本分析中的背痛患病率呈弱相关，但在低出生体重儿和足月儿之间没有差异。然而，这种小幅度的关联仅略高于显著性水平，似乎受到遗传因素和早期共同环境的影响。我们的研究结果表明，这些预测因素与成年人背痛之间直接关联的可能性不大。这些幻灯片可以在电子补充材料中检索到。
