无酶法通过聚合物 DNA zyme 纳米结构的靶标触发组装来定量细胞外体 microRNA。
Enzyme-free quantification of exosomal microRNA by the target-triggered assembly of the polymer DNAzyme nanostructure.
机构信息
Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
出版信息
Analyst. 2018 Feb 12;143(4):813-816. doi: 10.1039/c7an01691c.
PMID:29362731
Abstract
We herein report an efficient hybridization chain reaction (HCR)- and DNAzyme-based enzyme-free signal amplification for the detection of specific exosomal miRNAs in the culture medium of cancer cells and serum samples from cancer patients via the target-triggered self-assembly of the polymer DNAzyme nanostructure.
摘要
我们在此报告了一种基于杂交链式反应（HCR）和 DNA 酶的无酶信号放大方法，用于通过目标触发的聚合物 DNA 酶纳米结构的自组装来检测癌细胞培养介质和癌症患者血清样本中的特定外泌体 miRNAs。
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