自催化 DNA 酶组装用于放大的细胞内成像。
Autocatalytic DNAzyme assembly for amplified intracellular imaging.
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China.
出版信息
Chem Commun (Camb). 2020 Sep 29;56(77):11410-11413. doi: 10.1039/d0cc05257d.
PMID:32940259
Abstract
The autocatalytic HCR-DNAzyme platform was constructed as a versatile amplification platform for intracellular microRNA imaging by integrating hybridization chain reaction (HCR) circuit with DNAzyme biocatalysis. The HCR-assembled multifunctional DNAzyme nanowires produce new HCR triggers and numerous transducer DNAzyme amplifier, and thus shows great promise in earlier cancer diagnosis.
摘要
自催化 HCR-DNAzyme 平台通过将杂交链式反应 (HCR) 与 DNAzyme 生物催化相结合，构建了一种用于细胞内 microRNA 成像的多功能放大平台。HCR 组装的多功能 DNAzyme 纳米线产生新的 HCR 触发子和大量的传感器 DNAzyme 放大器，因此在早期癌症诊断中具有广阔的应用前景。
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