Lienhart A, Meistelman C, Maurel C, Deriaz H, Nebout T, Viars P
Ann Fr Anesth Reanim. 1985;4(6):471-6. doi: 10.1016/s0750-7658(85)80243-4.
The mechanical response of the adductor pollicis to a 0.15 Hz stimulation of the ulnar nerve was studied in 35 unpremedicated adult patients (mean age 38 yr) under general anaesthesia using thiopentone, fentanyl and a N2O/O2 mixture under mechanical ventilation. PaCO2, pH, K, Ca, Mg plasma levels and temperature were in the normal range. Each patient received a single bolus of atracurium dibesylate: 0.10 mg . kg-1 (n = 11), 0.15 mg . kg-1 (n = 10), 0.20 mg . kg-1 (n = 11) or 0.30 mg . kg-1 (n = 4). The dose-response curve was constructed using the log-probit method for 0.10, 0.15, 0.20 mg . kg-1 doses, giving neuromuscular blocks greater than 0% and less than 0.20 mg . kg-1. The 0.20 mg . kg-1 dose had an onset time of 6.1 +/- 0.6 min, duration 0-90% of 34.3 +/- 3.2 min and a recovery index 25-75% of 10.9 +/- 1.0 min. The 0.3 mg . kg-1 dose resulted in onset time of 4.7 +/- 1.3 min, duration of 39.9 +/- 3.7 min and a recovery index of 10.7 +/- 1.8 min. Thus atracurium dibesylate seemed to be an agent of intermediate potency. Onset time was approximately the same as that for other non-depolarizing neuromuscular blocking drugs, but duration of action and recovery index were quite shorter, except for vecuronium bromide.
在35例未使用术前药的成年患者（平均年龄38岁）中，在全身麻醉下使用硫喷妥钠、芬太尼和N2O/O2混合气体并机械通气，研究了拇收肌对尺神经0.15 Hz刺激的机械反应。动脉血二氧化碳分压（PaCO2）、pH值、血钾、血钙、血镁水平及体温均在正常范围内。每位患者单次静脉注射阿曲库铵二苯磺酸盐：0.10 mg·kg-1（n = 11）、0.15 mg·kg-1（n = 10）、0.20 mg·kg-1（n = 11）或0.30 mg·kg-1（n = 4）。采用对数概率法构建0.10、0.15、0.20 mg·kg-1剂量的剂量-反应曲线，这些剂量产生的神经肌肉阻滞大于0%且小于0.20 mg·kg-1。0.20 mg·kg-1剂量的起效时间为6.1±0.6分钟，0至90%阻滞持续时间为34.3±3.2分钟，恢复指数（25%至75%恢复时间）为10.9±1.0分钟。0.3 mg·kg-1剂量的起效时间为4.7±1.3分钟，持续时间为39.9±3.7分钟，恢复指数为10.7±1.8分钟。因此，阿曲库铵二苯磺酸盐似乎是一种中效药物。起效时间与其他非去极化神经肌肉阻滞药物大致相同，但作用持续时间和恢复指数相当短，除了维库溴铵。
