a Division of Rheumatology, Department of Internal Medicine , Hacettepe University Faculty of Medicine , Ankara , Turkey.
b Division of Rheumatology, Department of Pediatrics , Hacettepe University Faculty of Medicine , Ankara , Turkey , and.
Ups J Med Sci. 2018 Mar;123(1):57-61. doi: 10.1080/03009734.2017.1423425. Epub 2018 Jan 24.
Familial Mediterranean fever (FMF) is a periodic fever syndrome caused by MEFV mutations. FMF may be associated with psoriasis in some cases. The prevalence of psoriasis in the normal Turkish population is 0.42%. We aimed to investigate the prevalence of psoriasis among FMF patients and their relatives.
FMF patients followed at Hacettepe University Adult and Pediatric Rheumatology Departments between January and August 2016 were included. FMF patients/their relatives were accepted to have psoriasis if the diagnosis was made by a dermatologist.
A total of 351 FMF patients (177 adults; 174 children) were included. The median (min-max) age of adult and pediatric patients was 35 (19-63) and 10 (2-18) years, respectively. Thirteen (3.7%) FMF patients (11 adults, 2 children) had psoriasis. Psoriasis was more common in adult than pediatric patients (p = 0.02). Psoriasis was present in 22 (12.4%) of adult and 9 (5.2%) of pediatric patients' relatives (p = 0.023). The frequency of psoriasis in ≥1 relatives of FMF patients was found to be 8.8%. Abdominal pain and fever were significantly higher, and arthralgia, arthritis, pleural chest pain, and pericarditis were significantly less frequent in the pediatric group than in adults (p < 0.05).
Psoriasis was more common in FMF patients than in the normal population. Thus, FMF patients should be questioned and carefully examined for psoriasis lesions and psoriasis family history. Prospective multicenter studies may be important to find the incidence of psoriasis in FMF.
家族性地中海热（FMF）是一种由 MEFV 突变引起的周期性发热综合征。FMF 在某些情况下可能与银屑病有关。正常土耳其人群中银屑病的患病率为 0.42%。我们旨在调查 FMF 患者及其亲属中银屑病的患病率。
2016 年 1 月至 8 月期间，我们在哈塞特佩大学成人和儿科风湿病科收治的 FMF 患者纳入本研究。如果皮肤科医生做出诊断，FMF 患者/其亲属被认为患有银屑病。
共纳入 351 例 FMF 患者（177 例成人；174 例儿童）。成人和儿科患者的中位（最小-最大）年龄分别为 35（19-63）和 10（2-18）岁。13 例（3.7%）FMF 患者（11 例成人，2 例儿童）患有银屑病。成人中银屑病的发病率高于儿科患者（p=0.02）。成人患者中 22 例（12.4%）和儿科患者中 9 例（5.2%）的亲属存在银屑病（p=0.023）。FMF 患者≥1 位亲属中银屑病的发生率为 8.8%。儿科组腹痛和发热的发生率明显较高，而关节痛、关节炎、胸膜炎胸痛和心包炎的发生率明显较低（p<0.05）。
FMF 患者中银屑病的发病率高于普通人群。因此，FMF 患者应被询问并仔细检查银屑病皮损和银屑病家族史。前瞻性多中心研究可能对发现 FMF 中的银屑病发病率很重要。
