针对 AChE 和 BChE 的白蛋白衍生肽的抗阿尔茨海默病活性及分子机制。
Anti-Alzheimers activity and molecular mechanism of albumin-derived peptides against AChE and BChE.
机构信息
College of Food Science and Engineering, Bohai University, Jinzhou 121013, P.R. China.
出版信息
Food Funct. 2018 Feb 21;9(2):1173-1178. doi: 10.1039/c7fo01462g.
Alzheimer's disease (AD) is a global health issue affecting millions of elderly people worldwide. The aim of the present study was to identify novel anti-AD peptides isolated from albumin. Anti-AD activities of the peptides were evaluated via inhibitory activities on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Furthermore, the potential molecular mechanisms of the KLPGF/AChE were investigated by CDOCKER of Discovery studio 2017. The results revealed that peptide KLPGF could effectively inhibit AChE with an inhibition rate of 61.23% at a concentration of 50 μg mL. In addition, the peptide KLPGF came in contact with acylation sites and peripheral anion sites of AChE. The present study demonstrates that the peptide KLPGF could become a potential functional food intervention in AD.
阿尔茨海默病（AD）是一个全球性的健康问题，影响着全球数以百万计的老年人。本研究的目的是从白蛋白中鉴定出具有新型抗 AD 活性的肽。通过对乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的抑制活性来评估肽的抗 AD 活性。此外，还通过 Discovery studio 2017 的 CDOCKER 研究了 KLPGF/AChE 的潜在分子机制。结果表明，肽 KLPGF 可有效抑制 AChE，在 50 μg/mL 的浓度下抑制率为 61.23%。此外，肽 KLPGF 与 AChE 的酰化位点和外周阴离子位点结合。本研究表明，肽 KLPGF 可能成为 AD 的一种潜在功能性食品干预物质。
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