5-氟尿嘧啶合成代谢的中间产物掺入结直肠癌。
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
作者信息
Giles G R, Woodhouse L, Finan P J, Chisholm E M
出版信息
Gut. 1986 Feb;27(2):176-81. doi: 10.1136/gut.27.2.176.
Abstract
In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no evidence, however, that some patients had a selectively increased ability to incorporate 5-FU into their tumours. Overall higher concentrations of tumour incorporation of 5-FU were found after bolus injection rather than the infusion method, although this difference is statistically not significant.
摘要
在18例患者中，测定了静脉推注或持续输注5-氟尿嘧啶（5-FU）后，正常结肠黏膜和结直肠癌组织中5-FU的中间合成代谢产物。与正常结肠组织相比，癌组织中5-FU产物的总浓度更高。然而，没有证据表明某些患者将5-FU掺入肿瘤的能力有选择性地增加。尽管这种差异在统计学上不显著，但推注注射后5-FU的肿瘤掺入总体浓度高于输注方法。
相似文献
1
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.5-氟尿嘧啶合成代谢的中间产物掺入结直肠癌。
Gut. 1986 Feb;27(2):176-81. doi: 10.1136/gut.27.2.176.
2
The relationship between plasma pharmacokinetics and tissue metabolites of 5-fluorouracil (5-FU) in patients with colorectal cancer.
Eur J Surg Oncol. 1987 Aug;13(4):349-53.
3
A comparison of 5-fluorouracil metabolism in human colorectal cancer and colon mucosa.
Cancer. 1991 Nov 1;68(9):1903-9. doi: 10.1002/1097-0142(19911101)68:9<1903::aid-cncr2820680910>3.0.co;2-9.
4
Thymidylate synthase from untreated human colorectal cancer and colonic mucosa: enzyme activity and inhibition by 5-fluoro-2'-deoxy-uridine-5'-monophosphate.未经治疗的人类结直肠癌和结肠黏膜中的胸苷酸合成酶：酶活性及5-氟-2'-脱氧尿苷-5'-单磷酸对其的抑制作用
Eur J Cancer. 1991;27(3):263-7. doi: 10.1016/0277-5379(91)90512-c.
5
Plasma concentrations of 5-fluorouracil and its metabolites in colon cancer patients.结肠癌患者血浆中5-氟尿嘧啶及其代谢物的浓度。
Pharmacol Res. 2004 Aug;50(2):173-9. doi: 10.1016/j.phrs.2004.01.006.
6
Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue.正常和恶性人类结肠直肠组织中与5-氟尿嘧啶早期代谢相关的组织酶的比较水平。
Br J Cancer. 1984 Nov;50(5):711-5. doi: 10.1038/bjc.1984.240.
7
Selective modulation of 5-fluorouracil action in patients with colorectal carcinoma.
Chemioterapia. 1985 Oct;4(5):377-82.
8
Preliminary evidence that incorporation of 5-fluorouracil into RNA correlates with antitumor response.
Cancer Invest. 1992;10(4):265-9. doi: 10.3109/07357909209032750.
9
Effects of oxaliplatin and CPT-11 on cytotoxicity and nucleic acid incorporation of the fluoropyrimidines.奥沙利铂和伊立替康对氟嘧啶细胞毒性及核酸掺入的影响。
J Cancer Res Clin Oncol. 2004 Aug;130(8):453-9. doi: 10.1007/s00432-004-0575-6. Epub 2004 Jun 15.
10
Nonlinear pharmacokinetic characteristics of 5-fluorouracil (5-FU) in colorectal cancer patients.
Eur J Clin Pharmacol. 1987;32(4):411-8. doi: 10.1007/BF00543978.
引用本文的文献
1
Temporary blood flow stasis with degradable starch microspheres (DSM) for liver metastases in a rat model.在大鼠模型中使用可降解淀粉微球（DSM）实现肝脏转移灶的临时血流停滞。
Gut. 1987 Oct;28(10):1201-7. doi: 10.1136/gut.28.10.1201.
本文引用的文献
1
Further clinical studies with 5-fluorouracil.5-氟尿嘧啶的进一步临床研究。
J Natl Cancer Inst. 1959 Mar;22(3):497-507.
2
Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.肿瘤组织及配对的正常胃肠道黏膜中嘧啶核苷磷酸化酶的活性
Gut. 1982 Dec;23(12):1072-6. doi: 10.1136/gut.23.12.1072.
3
Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue.正常和恶性人类结肠直肠组织中与5-氟尿嘧啶早期代谢相关的组织酶的比较水平。
Br J Cancer. 1984 Nov;50(5):711-5. doi: 10.1038/bjc.1984.240.
4
Preliminary studies of the uridine kinase activity of human colorectal adenocarcinomas.
Cancer. 1981 Sep 1;48(5):1200-6. doi: 10.1002/1097-0142(19810901)48:5<1200::aid-cncr2820480525>3.0.co;2-p.
5
Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.
Cancer Res. 1980 May;40(5):1431-7.
6
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.
Cancer Treat Rep. 1981;65 Suppl 3:57-61.
7
The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.
Biochemistry. 1969 May;8(5):2057-62. doi: 10.1021/bi00833a041.
8
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.胸苷酸合成酶：5-氟-2'-脱氧尿苷酸的抑制机制。
Biochem Biophys Res Commun. 1972 Sep 26;48(6):1565-71. doi: 10.1016/0006-291x(72)90892-3.
9
Fluorinated pyrimidines.
Prog Nucleic Acid Res Mol Biol. 1965;4:1-50. doi: 10.1016/s0079-6603(08)60783-7.
10
Comparison of continuously infused 5-fluorouracil with bolus injection in treatment of patients with colorectal adenocarcinoma.持续输注5-氟尿嘧啶与推注给药治疗结肠腺癌患者的比较。
Cancer. 1975 Jul;36(1):123-8. doi: 10.1002/1097-0142(197507)36:1<123::aid-cncr2820360108>3.0.co;2-c.
Zotero 插件