5-氟尿嘧啶合成代谢的中间产物掺入结直肠癌。
Incorporation of intermediary products of 5-FU anabolism into colorectal cancer.
作者信息
Giles G R, Woodhouse L, Finan P J, Chisholm E M
出版信息
Gut. 1986 Feb;27(2):176-81. doi: 10.1136/gut.27.2.176.
Abstract
In 18 patients intermediary anabolic metabolites of 5-FU were measured in normal colonic mucosa and colorectal cancer tissue of intravenous bolus injection or continuous infusion. Higher total concentrations of 5-FU products were found in the cancers when compared with normal colonic tissue. There appeared to be no evidence, however, that some patients had a selectively increased ability to incorporate 5-FU into their tumours. Overall higher concentrations of tumour incorporation of 5-FU were found after bolus injection rather than the infusion method, although this difference is statistically not significant.
摘要
在18例患者中，测定了静脉推注或持续输注5-氟尿嘧啶（5-FU）后，正常结肠黏膜和结直肠癌组织中5-FU的中间合成代谢产物。与正常结肠组织相比，癌组织中5-FU产物的总浓度更高。然而，没有证据表明某些患者将5-FU掺入肿瘤的能力有选择性地增加。尽管这种差异在统计学上不显著，但推注注射后5-FU的肿瘤掺入总体浓度高于输注方法。
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本文引用的文献
1
Further clinical studies with 5-fluorouracil.5-氟尿嘧啶的进一步临床研究。
J Natl Cancer Inst. 1959 Mar;22(3):497-507.
2
Pyrimidine nucleoside phosphorylase activity in tumour and matched normal gastrointestinal mucosa.肿瘤组织及配对的正常胃肠道黏膜中嘧啶核苷磷酸化酶的活性
Gut. 1982 Dec;23(12):1072-6. doi: 10.1136/gut.23.12.1072.
3
Comparative levels of tissue enzymes concerned in the early metabolism of 5-fluorouracil in normal and malignant human colorectal tissue.正常和恶性人类结肠直肠组织中与5-氟尿嘧啶早期代谢相关的组织酶的比较水平。
Br J Cancer. 1984 Nov;50(5):711-5. doi: 10.1038/bjc.1984.240.
4
Preliminary studies of the uridine kinase activity of human colorectal adenocarcinomas.人结肠腺癌尿苷激酶活性的初步研究。
Cancer. 1981 Sep 1;48(5):1200-6. doi: 10.1002/1097-0142(19810901)48:5<1200::aid-cncr2820480525>3.0.co;2-p.
5
Mechanisms of sensitivity and resistance of murine tumors to 5-fluorouracil.
Cancer Res. 1980 May;40(5):1431-7.
6
The potential for clinical application of in vitro assays predicting 5-FU sensitivity in man.体外检测预测人体5-氟尿嘧啶敏感性的临床应用潜力。
Cancer Treat Rep. 1981;65 Suppl 3:57-61.
7
The synthesis of 5-fluorouridine 5'-phosphate by a pyrimidine phosphoribosyltransferase of mammalian origin. I. Some properties of the enzyme from P1534J mouse leukemic cells.
Biochemistry. 1969 May;8(5):2057-62. doi: 10.1021/bi00833a041.
8
Thymidylate synthetase: mechanism of inhibition by 5-fluoro-2'-deoxyuridylate.胸苷酸合成酶：5-氟-2'-脱氧尿苷酸的抑制机制。
Biochem Biophys Res Commun. 1972 Sep 26;48(6):1565-71. doi: 10.1016/0006-291x(72)90892-3.
9
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Prog Nucleic Acid Res Mol Biol. 1965;4:1-50. doi: 10.1016/s0079-6603(08)60783-7.
10
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Cancer. 1975 Jul;36(1):123-8. doi: 10.1002/1097-0142(197507)36:1<123::aid-cncr2820360108>3.0.co;2-c.
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