Division of Infectious Diseases, Department of Medicine, Weill Cornell Medicine and New York Presbyterian Hospital, New York, New York, USA.
Department of Healthcare Policy and Research, Weill Cornell Medicine, New York, New York, USA.
J Clin Pathol. 2018 Jul;71(7):626-630. doi: 10.1136/jclinpath-2017-204777. Epub 2018 Jan 24.
Mycobacterial spindle cell pseudotumour (MSP) is a rare disease characterised by tumour-like local proliferation of spindle-shaped histiocytes containing acid-fast positive mycobacteria. The aim of this literature review is to describe the clinical parameters and treatment outcomes of patients with MSP.
A literature search was conducted using the search terms related to mycobacteria and spindle cell tumours. A previously unreported stem cell transplant recipient from our institution diagnosed with MSP was also included. Demographics, comorbidities, site of infection, treatment and clinical outcomes were analysed.
Fifty-one patients were analysed. Twenty-six (51%) had HIV infection. complex was the most frequent organism isolated in 24 (47.1%) followed by complex in eight (16%) cases. Lymph nodes were the most common site of infection (45.1%). Twenty (39.2%) patients received antimycobacterial agents, 12 (23.5%) underwent surgical resection and six (11.8%) received antimycobacterial agents plus surgery. Treatment was successful in 24 (47.1%) patients and failed in 15 (29.4%); 13 of these 15 patients died. Antimycobacterial therapy was significantly associated with successful outcome compared with surgical resection or no treatment (P<0.001).
MSP is a rare condition associated primarily with immunodeficiencies. Antimycobacterial therapy is significantly associated with outcome.
分枝杆菌梭形细胞假肿瘤（MSP）是一种罕见疾病，其特征为梭形组织细胞呈肿瘤样局部增殖，其中含有抗酸阳性分枝杆菌。本文旨在描述 MSP 患者的临床参数和治疗结局。
使用与分枝杆菌和梭形细胞肿瘤相关的检索词进行文献检索，并纳入了我们机构中一位此前未报道的患有 MSP 的干细胞移植受者。分析了患者的人口统计学、合并症、感染部位、治疗方法和临床结局。
共分析了 51 例患者。26 例（51%）患者 HIV 感染。24 例（47.1%）患者最常分离出 复合群，8 例（16%）患者分离出 复合群。淋巴结是最常见的感染部位（45.1%）。20 例（39.2%）患者接受了抗分枝杆菌药物治疗，12 例（23.5%）患者接受了手术切除，6 例（11.8%）患者接受了抗分枝杆菌药物联合手术治疗。24 例（47.1%）患者的治疗成功，15 例（29.4%）患者的治疗失败，其中 13 例死亡。与手术切除或未治疗相比，抗分枝杆菌治疗与良好的结局显著相关（P<0.001）。
MSP 是一种罕见的疾病，主要与免疫缺陷有关。抗分枝杆菌治疗与结局显著相关。
