Kirchner Allison, Sergeyenko Artem, Keane Janice, Belinski Kenneth, Liu Wenhua
University of Illinois College of Medicine, Chicago, Illinois, USA.
Skin MD LLC, Chicago, Illinois, USA.
J Cutan Pathol. 2021 Sep;48(9):1178-1181. doi: 10.1111/cup.14042. Epub 2021 May 17.
Mycobacterial spindle cell pseudotumor (MSP) is a non-neoplastic condition that is characterized by spindle-shaped histiocytes colonized by mycobacteria. MSP is most commonly diagnosed in the immunocompromised and, while MSP can occur throughout the body, the most common sites of MSP involvement are the lymph nodes and the skin. To diagnose MSP, histopathological analysis typically demonstrates the presence of inflammatory cells, in addition to spindle cells and the unequivocal mycobacteria, which guides the diagnosis away from potential neoplasms. If properly diagnosed and treated with appropriate antibiotic therapy, patients tend to experience almost complete resolution of their symptoms. MSP is a rare condition; to our knowledge, there have only been 11 documented cases of cutaneous MSP, including the one introduced in this report. Here, we present a unique case of a 50-year-old female on chronic immunosuppressive therapy diagnosed with cutaneous MSP in the absence of inflammatory cells on pathology.
分枝杆菌性梭形细胞假瘤（MSP）是一种非肿瘤性疾病，其特征是梭形组织细胞被分枝杆菌定植。MSP最常见于免疫功能低下者，虽然MSP可发生于全身，但最常累及的部位是淋巴结和皮肤。为诊断MSP，组织病理学分析通常除了显示梭形细胞和明确的分枝杆菌外，还可见炎症细胞，这有助于将诊断与潜在肿瘤区分开来。如果诊断正确并接受适当的抗生素治疗，患者的症状往往几乎完全缓解。MSP是一种罕见疾病；据我们所知，仅有11例皮肤MSP的文献记载病例，包括本报告中介绍的这一例。在此，我们报告一例独特病例，一名50岁接受慢性免疫抑制治疗的女性被诊断为皮肤MSP，但其病理检查未见炎症细胞。
