Palacio Evandro Pereira, Pereira Gilberto José Cação, Silvares Paulo Roberto de Almeida, Stasi Gabriel Guimarães Di, Staut Caio de Andrade, Sardenberg Trajano
Departamento de Cirurgia e Ortopedia, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (UNESP), Botucatu, SP, Brazil.
Faculdade de Medicina de Marília, Marília, SP, Brazil.
Rev Bras Ortop. 2017 Dec 6;53(1):53-59. doi: 10.1016/j.rboe.2017.11.010. eCollection 2018 Jan-Feb.
Synthetic adhesives are used by various medical specialties, especially in surgery; however, studies reporting their use in orthopedic practice are scarce. The aim of this study was to compare the results in using ethyl-2-cyanoacrylate or butyl-2-cyanoacrylate in the treatment of fractures in rats.
This was an experimental prospective controlled study in 90 rats, with humerus, femur, and tibia fractures, treated with ethyl-2-cyanoacrylate (SB group; = 45) or butyl-2-cyanoacrylate (HA group; = 45). Biomechanical and histomorphometric analyses were performed at three different moments (60, 120, and 180 days); besides a clinical study performed weekly by measurement of the animals body mass.
No differences were observed regarding body mass ( = 0.07). In both groups, there were no significant differences regarding maximum load ( = 0.6), yield point strength ( = 0.6), and stiffness coefficient ( = 0.4) of the femurs. The same was observed in tibias for maximum load ( = 0.4), yield point strength ( = 0.7), and stiffness coefficient ( = 0.6). The humerus from both groups had similar bone callus area ( = 0.66). In both groups, there were no statistical differences related to inflammatory cells ( = 0.4), osteoblasts ( = 0.2), and osteoclasts ( = 0.2).
Ethyl-2-cyanoacrylate was more effective than butyl-2-cyanoacrylate in the treatment of fractures in rats.
合成粘合剂被多个医学专科所使用，尤其是在外科手术中；然而，报道其在骨科实践中应用的研究却很稀少。本研究的目的是比较使用2-氰基丙烯酸乙酯或2-氰基丙烯酸丁酯治疗大鼠骨折的效果。
这是一项对90只大鼠进行的实验性前瞻性对照研究，这些大鼠有肱骨、股骨和胫骨骨折，分别用2-氰基丙烯酸乙酯治疗（SB组；n = 45）或2-氰基丙烯酸丁酯治疗（HA组；n = 45）。在三个不同时间点（60、120和180天）进行生物力学和组织形态计量学分析；此外，每周通过测量动物体重进行一项临床研究。
在体重方面未观察到差异（P = 0.07）。在两组中，股骨的最大负荷（P = 0.6）、屈服点强度（P = 0.6）和刚度系数（P = 0.4）均无显著差异。胫骨在最大负荷（P = 0.4）、屈服点强度（P = 0.7）和刚度系数（P = 0.6）方面也观察到同样情况。两组肱骨的骨痂面积相似（P = 0.66）。在两组中，与炎性细胞（P = 0.4）、成骨细胞（P = 0.2）和破骨细胞（P = 0.2）相关的方面均无统计学差异。
在治疗大鼠骨折方面，2-氰基丙烯酸乙酯比2-氰基丙烯酸丁酯更有效。
