Madden J J, Falek A, Shafer D A, Glick J H
Proc Natl Acad Sci U S A. 1979 Nov;76(11):5769-73. doi: 10.1073/pnas.76.11.5769.
DNA repair synthesis in leukocytes stressed by far UV irradiation was studied in 90 normal individuals, 38 street-heroin addicts, and 18 methadone maintenance patients. Age, sex, coffee use, and alcohol use had no significant effect on the maximal repair synthesis response of the control subjects, but smoking tobacco significantly decreased the mean response and variance when compared with nonsmoking controls. Heroin addiction had an even more pronounced negative effect, and this may be related to the high rate of chromosome aberrations found in this population. Half of the addicts tested were incapable of repairing UV fluences one-quarter as large as those repaired by the control subjects (5 J/m2 and 20 J/m2, respectively) in the 2-hr assay period. Long-term methadone treatment ameliorated the effects of the street heroin, just as it resulted in a decrease of the chromosome aberration frequency.
对90名正常个体、38名街头海洛因成瘾者和18名美沙酮维持治疗患者，研究了远紫外线照射应激下白细胞中的DNA修复合成。年龄、性别、咖啡饮用和酒精饮用对对照受试者的最大修复合成反应无显著影响，但与不吸烟对照相比，吸烟显著降低了平均反应和方差。海洛因成瘾有更明显的负面影响，这可能与该人群中发现的高染色体畸变率有关。在2小时的检测期内，一半接受检测的成瘾者修复紫外线通量的能力仅为对照受试者的四分之一（分别为5 J/m²和20 J/m²）。长期美沙酮治疗改善了街头海洛因的影响，同样也导致了染色体畸变频率的降低。
