Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-Dong, Gangnam-gu, Seoul, 135-710, Korea.
Department of Radiology, Chungnam National University Hospital, Chungnam National University College of Medicine, Daejeon, Republic of Korea.
Eur Radiol. 2018 Jun;28(6):2561-2571. doi: 10.1007/s00330-017-5248-3. Epub 2018 Jan 24.
To evaluate the correlation between grade of hepatic neuroendocrine tumours (NETs) according to the 2010 World Health Organization (WHO) classification and the apparent diffusion coefficient (ADC) and to assess whether ADC value can predict overall survival (OS) after diagnosis of hepatic NETs.
The study included 63 patients who underwent magnetic resonance (MR) imaging with diffusion-weighted images for the evaluation of hepatic NETs. The correlation between qualitative and quantitative MR imaging findings, including ADC values, and WHO classifications was assessed. The association between ADC value and OS was analyzed.
The ADC values and WHO classification of hepatic NETs were moderately negatively correlated in a statistically significant manner (ρ = -0.57, p < 0.001). The OS rates were significantly different according to the ADC value (low ADC vs. high ADC, p = 0.006) as well as WHO classifications (G1+ G2 vs. G3, p = 0.038). However, multivariate analysis revealed that the only independent predictor for OS was a low ADC value (hazard ratio: 3.37, p = 0.010).
There was a significant correlation between the ADC value of hepatic NETs and the WHO tumour grade. Additionally, the ADC value of a hepatic NET might be more accurate than the current WHO tumour grade for predicting OS.
• ADC values of hepatic NET and WHO tumour grade were negatively correlated. • Lower ADC values of hepatic NET were significantly correlated with worse OS. • ADC value might be more accurate than WHO grade for predicting OS.
评估根据 2010 年世界卫生组织（WHO）分类的肝脏神经内分泌肿瘤（NETs）分级与表观扩散系数（ADC）之间的相关性，并评估 ADC 值是否可以预测肝脏 NETs 诊断后的总生存期（OS）。
本研究纳入了 63 例经磁共振（MR）成像扩散加权成像评估肝脏 NETs 的患者。评估了定性和定量 MR 成像发现（包括 ADC 值）与 WHO 分类之间的相关性。分析了 ADC 值与 OS 之间的关联。
肝脏 NETs 的 ADC 值与 WHO 分级呈中度负相关（ρ=-0.57，p＜0.001）。根据 ADC 值（低 ADC 与高 ADC，p=0.006）和 WHO 分级（G1+G2 与 G3，p=0.038），OS 率有显著差异。然而，多变量分析显示，OS 的唯一独立预测因素是低 ADC 值（风险比：3.37，p=0.010）。
肝脏 NETs 的 ADC 值与 WHO 肿瘤分级之间存在显著相关性。此外，肝脏 NETs 的 ADC 值可能比目前的 WHO 肿瘤分级更准确地预测 OS。
• 肝脏 NETs 的 ADC 值与 WHO 肿瘤分级呈负相关。
• 肝脏 NETs 的 ADC 值较低与 OS 较差显著相关。
• ADC 值可能比 WHO 分级更准确地预测 OS。
