Lamerton A J, Nicolaides A N, Sutton D, Eastcott H H
Int Angiol. 1985 Jan-Mar;4(1):93-7.
The aim of the study was to measure the haemodynamic effect of percutaneous transluminal angioplasty (PTA). Twenty-one consecutive patients with unilateral stenosis of the iliac (n = 13) or femoropopliteal arteries (n = 8) causing intermittent claudication were studied with ankle and brachial systolic pressure measurements before and after PTA and at six monthly intervals. In 15 patients, the pressures were measured not only at rest, but after exercise on a standard treadmill. There were six technical failures. All of the remaining patients were improved clinically and objectively. The resting pressure index increased from mean (+/- ISD) of 0.65 +/- 0.22 to 0.88 +/- 0.17 and the postexercise index from 0.43 +/- 0.21 to 0.82 +/- 0.22. The preoperative claudication distance was improved from 83 m +/- 31 to 252 m +/- 104 and the recovery time from 6.3 mins +/- 5.7 to 1.5 mins +/- 2.3. During the follow up period of six weeks to 2 1/2 years, the initial improvement was maintained and there were no failures clinically or on further Doppler examination. The results suggest that for patient with a single significant stenosis, PTA is an effective alternative method of treating claudication.
本研究的目的是测量经皮腔内血管成形术（PTA）的血液动力学效应。对21例因单侧髂动脉狭窄（n = 13）或股腘动脉狭窄（n = 8）导致间歇性跛行的连续患者，在PTA术前、术后及每间隔6个月时进行踝部和肱部收缩压测量。15例患者不仅在静息状态下测量了血压，还在标准跑步机上运动后进行了测量。有6例技术失败。其余所有患者在临床和客观指标上均有改善。静息压力指数从平均（±标准差）0.65±0.22增至0.88±0.17，运动后指数从0.43±0.21增至0.82±0.22。术前跛行距离从83 m±31增至252 m±104，恢复时间从6.3分钟±5.7减至1.5分钟±2.3。在6周至2年半的随访期内，最初的改善得以维持，临床及进一步的多普勒检查均未出现失败情况。结果表明，对于单一严重狭窄的患者，PTA是治疗跛行的一种有效替代方法。
