1 The Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK.
2 South London and Maudsley NHS Foundation Trust, UK.
J Psychopharmacol. 2018 May;32(5):497-508. doi: 10.1177/0269881117747579. Epub 2018 Jan 25.
Abnormalities of the glutamate system are increasingly implicated in schizophrenia but their exact nature remains unknown. Proton magnetic resonance spectroscopy (H-MRS), while fundamental in revealing glutamatergic alterations in schizophrenia, has, until recently, been significantly limited and thought to only provide static measures. Functional magnetic resonance spectroscopy (fMRS), which uses sequential scans for dynamic measurement of a range of brain metabolites in activated brain areas, has lately been applied to a variety of task or stimulus conditions, producing interesting insights into neurometabolite responses to neural activation. Here, we summarise the existing H-MRS studies of brain glutamate in schizophrenia. We then present a comprehensive review of research studies that have utilised fMRS, and lastly consider how fMRS methods might further the understanding of glutamatergic abnormalities in schizophrenia.
谷氨酸系统的异常与精神分裂症的关系日益密切，但具体性质尚不清楚。质子磁共振波谱（H-MRS）虽然是揭示精神分裂症中谷氨酸能改变的基础，但直到最近，它还受到很大限制，被认为只能提供静态测量。功能磁共振波谱（fMRS）利用连续扫描对激活脑区的一系列脑代谢物进行动态测量，最近已应用于各种任务或刺激条件，为神经代谢物对神经激活的反应提供了有趣的见解。在这里，我们总结了精神分裂症中大脑谷氨酸的现有 H-MRS 研究。然后，我们全面回顾了利用 fMRS 的研究，并最后考虑了 fMRS 方法如何进一步了解精神分裂症中谷氨酸能异常。
