搁浅于意大利的鲸类动物的神经病理学发现（2002 - 2014年）

NEUROPATHOLOGIC FINDINGS IN CETACEANS STRANDED IN ITALY (2002-14).

作者信息

Pintore Maria Domenica, Mignone Walter, Di Guardo Giovanni, Mazzariol Sandro, Ballardini Marco, Florio Caterina Lucia, Goria Maria, Romano Angelo, Caracappa Santo, Giorda Federica, Serracca Laura, Pautasso Alessandra, Tittarelli Cristiana, Petrella Antonio, Lucifora Giuseppe, Di Nocera Fabio, Uberti Barbara Degli, Corona Cristiano, Casalone Cristina, Iulini Barbara

机构信息

1 National Reference Center for Diagnostic Activities on Stranded Marine Mammals (C.Re.Di.Ma.)-Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta, via Bologna 148, 10154 Torino, Italy.

2 National Reference Center for Diagnostic Activities on Stranded Marine Mammals (C.Re.Di.Ma.)-Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle D'Aosta, via Nizza 4, 18100 Imperia, Italy.

出版信息

J Wildl Dis. 2018 Apr;54(2):295-303. doi: 10.7589/2017-02-035. Epub 2018 Jan 25.

DOI:10.7589/2017-02-035

PMID:29369721

Abstract

We summarized the neuropathologic findings in 60 cetaceans stranded along the Italian coastline from 2002 to 2014. The following neuropathologic changes were detected in 45% (27/60) of animals: nonsuppurative meningo-encephalitides (30%, 18/60), nonspecific lesions (12%, 7/60), suppurative encephalitis (2%, 1/60), and neoplasm (2%, 1/60). No histologic lesions were found in 47% (28/60) of the specimens. Five (8%, 5/60) samples were unsuitable for analysis. Analysis with PCR detected Brucella spp., morbillivirus, and Toxoplasma gondii infection in one, six, and seven individuals, respectively. Immunohistochemical analysis confirmed positivity for morbillivirus and for T. gondii infection in three cases each. No evidence of the scrapie-associated prion protein PrPSc was detected. Our findings underscore the importance of an adequate surveillance system for monitoring aquatic mammal pathologies and for protecting both animal and human health.

摘要

我们总结了2002年至2014年期间搁浅在意大利海岸线的60头鲸类动物的神经病理学发现。在45%（27/60）的动物中检测到以下神经病理学变化：非化脓性脑膜脑炎（30%，18/60）、非特异性病变（12%，7/60）、化脓性脑炎（2%，1/60）和肿瘤（2%，1/60）。47%（28/60）的标本未发现组织学病变。5个（8%，5/60）样本不适于分析。PCR分析分别在1头、6头和7头个体中检测到布鲁氏菌属、麻疹病毒和刚地弓形虫感染。免疫组织化学分析在3例中均证实了麻疹病毒和刚地弓形虫感染呈阳性。未检测到瘙痒病相关朊病毒蛋白PrPSc的证据。我们的研究结果强调了建立适当监测系统以监测水生哺乳动物病理学以及保护动物和人类健康的重要性。