结合黏连蛋白和凝聚素来看。

Stowers Institute for Medical Research, Kansas City, Missouri, United States of America.

Department of Oncology Biomarker Development, Genentech, Inc., South San Francisco, California, United States of America.

PLoS Genet. 2018 Jan 25;14(1):e1007118. doi: 10.1371/journal.pgen.1007118. eCollection 2018 Jan.

Structural maintenance of chromosome (SMC) protein complexes, including cohesin and condensin, are increasingly being recognized for their important role in cancer and development, making it critical that we understand how these evolutionarily conserved multi-subunit protein complexes associate with and organize the genome. We review adaptor proteins for SMC complexes and how these adaptors may capture SMC complexes following loop extrusion to provide a framework for chromosome organization.

越来越多的研究表明，染色体结构维持（SMC）蛋白复合物，包括黏合蛋白和凝聚素，在癌症和发育中起着重要作用，因此了解这些进化上保守的多亚基蛋白复合物如何与基因组相互作用和组织至关重要。我们回顾了 SMC 复合物的衔接蛋白，以及这些衔接蛋白如何在环挤出后捕获 SMC 复合物，为染色体组织提供一个框架。