a Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology , Wuhan , China.
Cancer Biol Ther. 2018 Mar 4;19(3):222-229. doi: 10.1080/15384047.2017.1416936. Epub 2018 Jan 25.
Phosphoinositide-3-kinase regulatory subunit 3(PIK3R3) is overexpressed in different types of human cancer. We previously reported the important role of PIK3R3 in colorectal cancer (CRC). However, the prognosis effect of PIK3R3 in CRC is still remaining unclear. In this study, we explored online clinical databases to analyze the prognosis differences between higher and lower expression of PIK3R3 in CRC patients. Interestingly, we found that better disease-free survival (DFS) were occurred in patients with higher expression of PIK3R3, but there is no significant difference in overall survival (OS). For further, we showed that PIK3R3 could enhance 5-FU induced apoptosis by regulating the expression of thymmidine phosphorylase (TP). In conclusion, PIK3R3 could be considered as a predictor of 5-FU sensitivity for personalized treatment, and a therapeutic target for colorectal cancer.
磷酸肌醇 3-激酶调节亚基 3（PIK3R3）在不同类型的人类癌症中过表达。我们之前报道了 PIK3R3 在结直肠癌（CRC）中的重要作用。然而，PIK3R3 在 CRC 中的预后作用仍不清楚。在这项研究中，我们探索了在线临床数据库，以分析 CRC 患者中 PIK3R3 高表达和低表达之间的预后差异。有趣的是，我们发现 PIK3R3 高表达的患者无病生存（DFS）更好，但总生存（OS）无显著差异。进一步研究表明，PIK3R3 通过调节胸苷磷酸化酶（TP）的表达来增强 5-FU 诱导的细胞凋亡。总之，PIK3R3 可作为 5-FU 敏感性的预测因子，用于个体化治疗，并作为结直肠癌的治疗靶点。
