1 Novartis Institutes for BioMedical Research, NIBR Informatics Department, Basel, Switzerland.
2 Cognizant Business Consulting, Zurich, Switzerland.
SLAS Discov. 2018 Jun;23(5):474-488. doi: 10.1177/2472555217752140. Epub 2018 Jan 25.
We describe the main characteristics of the Novartis Helios data analysis software system (Novartis, Basel, Switzerland) for plate-based screening and profiling assays, which was designed and built about 11 years ago. It has been in productive use for more than 10 years and is one of the important standard software applications running for a large user community at all Novartis Institutes for BioMedical Research sites globally. A high degree of automation is reached by embedding the data analysis capabilities into a software ecosystem that deals with the management of samples, plates, and result data files, including automated data loading. The application provides a series of analytical procedures, ranging from very simple to advanced, which can easily be assembled by users in very flexible ways. This also includes the automatic derivation of a large set of quality control (QC) characteristics at every step. Any of the raw, intermediate, and final results and QC-relevant quantities can be easily explored through linked visualizations. Links to global assay metadata management, data warehouses, and an electronic lab notebook system are in place. Automated transfer of relevant data to data warehouses and electronic lab notebook systems are also implemented.
我们描述了 Novartis Helios 数据分析软件系统（瑞士巴塞尔的诺华公司）的主要特点，该系统用于平板筛选和分析检测，大约在 11 年前设计和构建。它已经使用了 10 多年，是诺华生物医学研究所全球所有站点运行的大型用户社区的重要标准软件应用程序之一。通过将数据分析功能嵌入到一个处理样本、平板和结果数据文件管理的软件生态系统中，可以实现高度自动化，包括自动数据加载。该应用程序提供了一系列分析程序，从非常简单到高级的程序，用户可以非常灵活地以各种方式轻松组装。这还包括在每个步骤自动推导大量的质量控制（QC）特征。任何原始、中间和最终结果以及与 QC 相关的数量都可以通过链接的可视化轻松探索。与全球检测元数据管理、数据仓库和电子实验室笔记本系统的链接已经建立。还实现了将相关数据自动传输到数据仓库和电子实验室笔记本系统。
