Tanaka Mitsuru, Yasuoka Akihito, Yoshinuma Haruka, Saito Yoshikazu, Asakura Tomiko, Tanabe Soichi
a Nissin Global Innovation Center , Nissin Foods Holdings , Hachioji , Japan.
b Project on Health and Anti-Aging, Kanagawa Academy of Science and Technology , Kawasaki , Japan.
Biosci Biotechnol Biochem. 2018 Mar;82(3):497-506. doi: 10.1080/09168451.2018.1427551. Epub 2018 Jan 26.
We fed rats noodle (N) -diet containing 30 wt.% instant noodle with a 26% fat-to-energy ratio for 30 days (N-group). Compared with rats that were fed the same amount of nutrients (C-group), the N-group showed lower liver triacylglycerol levels and higher fecal cholesterol levels. We then analyzed transcriptome of the hypothalamic-pituitary (HP), the liver and the white adipose tissue (WAT). Thyroid stimulating hormone (Tshb), and its partner, glycoprotein hormone genes were up-regulated in the HP of N-group. Sterol regulatory element binding transcription factors were activated in the liver of N-group, while an up-regulation of the angiogenic signal occurred in the WAT of N-group. N-group showed higher urine noradrenaline (NA) level suggesting that these tissue signals are regulated by NA and Tshb. The N-diet contains 0.326 wt.% glutamate, 0.00236 wt.% 6-shogaol and Maillard reaction products. Our results suggest that these ingredients may affect lipid homeostasis via the HP axis.
我们给大鼠喂食含30 wt.%即食面的面条（N）-饮食，脂肪能量比为26%，持续30天（N组）。与喂食等量营养素的大鼠（C组）相比，N组的肝脏三酰甘油水平较低，粪便胆固醇水平较高。然后我们分析了下丘脑-垂体（HP）、肝脏和白色脂肪组织（WAT）的转录组。促甲状腺激素（Tshb）及其伴侣糖蛋白激素基因在N组的HP中上调。固醇调节元件结合转录因子在N组的肝脏中被激活，而血管生成信号在N组的WAT中上调。N组的尿去甲肾上腺素（NA）水平较高，表明这些组织信号受NA和Tshb调节。N-饮食含有0.326 wt.%谷氨酸、0.00236 wt.% 6-姜辣素和美拉德反应产物。我们的结果表明，这些成分可能通过HP轴影响脂质稳态。
