Department of Environmental Health, Graduate School of Yongin University , Yongin, 17092, Republic of Korea.
Department of Health, Environment and Safety, Eulji University , Seongnam, Gyeonggi, 13135, Republic of Korea.
Environ Sci Technol. 2018 Feb 6;52(3):1506-1513. doi: 10.1021/acs.est.7b00498. Epub 2018 Jan 26.
The compound 4-hydroxyphenyl 4-isoprooxyphenylsulfone (BPSIP), a derivative of bisphenol S (BPS), has been detected in thermal paper and human urine samples; however, its potential effects on the endocrine system are largely unknown. The present study was conducted to determine the adverse effects of BPSIP on egg production, relative organ weights, plasma levels of sex hormones, and transcription of genes related to the hypothalamus-pituitary-gonad (HPG) axis in zebrafish (Danio rerio). In male fish, the gonadosomatic index was significantly decreased at concentrations of 5 and 50 μg/L BPSIP. The estrogenic (increase in the 17β-estradiol/testosterone [E2/T] ratio) and antiandrogenic (decrease in T) effects were observed in fish exposed to BPSIP and males were more sensitive to the adverse effects than females. The changes in sex hormones were supported by the regulation of genes along the HPG axis, such as cyp19, 17βhsd, and cyp17 transcripts. Although the effective concentration for endocrine disruption was greater than that of BPS, the actions of BPSIP on the steroidogenic pathway were similar to the effects of BPS exposure.
4-羟基苯基 4-异丙烯基苯砜（BPSIP）是双酚 S（BPS）的一种衍生物，已在热敏纸和人类尿液样本中检测到；然而，其对内分泌系统的潜在影响在很大程度上尚不清楚。本研究旨在确定 BPSIP 对鱼类产卵、相对器官重量、血浆性激素水平以及下丘脑-垂体-性腺（HPG）轴相关基因转录的影响。在雄性鱼类中，5 和 50μg/L BPSIP 浓度可显著降低性腺指数。暴露于 BPSIP 的鱼类表现出雌激素（17β-雌二醇/睾酮[E2/T]比值升高）和抗雄激素（T 降低）作用，且雄性对这些不良反应更为敏感。HPG 轴相关基因如 cyp19、17βhsd 和 cyp17 的转录调控支持了性激素的变化。尽管内分泌干扰的有效浓度大于 BPS，但 BPSIP 对甾体生成途径的作用与 BPS 暴露的影响相似。
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