2型糖尿病肥胖青少年的脑灰质体积差异：一项初步研究。
Brain gray matter volume differences in obese youth with type 2 diabetes: a pilot study.
作者信息
Redel Jacob M, DiFrancesco Mark, Vannest Jennifer, Altaye Mekibib, Beebe Dean, Khoury Jane, Dolan Lawrence M, Lee Gregory, Brunner Hermine, Holland Scott, Brady Cassandra, Shah Amy S
机构信息
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Division of Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA, Phone: 513-636-4479, Fax: 513-803-1174.
出版信息
J Pediatr Endocrinol Metab. 2018 Mar 28;31(3):261-268. doi: 10.1515/jpem-2017-0349.
BACKGROUND
Adults with type 2 diabetes (T2D) have significantly lower gray matter volume (GMV) compared to healthy peers. Whether GMV differences exist in youth with T2D remains unclear. Thus, we compared global and regional GMV between obese youth with T2D with age, race and sex similar healthy controls.
METHODS
In a cross-sectional study, 20 obese youth with T2D underwent T1-weighted brain magnetic resonance imaging (MRI). Comparisons were made to 20 age, race and sex similar controls. Differences in global and regional GMV between groups were identified using voxel-based morphometry (VBM).
RESULTS
Youth with T2D had a significantly lower global GMV-to-intracranial volume ratio (0.51±0.02 in T2D vs. 0.53±0.02 in controls, p=0.02, Cohen's d=0.85). There were 14 regions where GMV was significantly lower in the T2D group, and nine of these were found in either the temporal or occipital lobes. There were six regions with increased GMV in T2D. All regional differences were significant at p<0.05 after adjusting for multiple comparisons.
CONCLUSIONS
Results from this pilot study show obese youth with T2D have significantly lower global GMV and regional GMV differences, when compared to their age, race and sex similar peers. Future work is needed to determine whether these brain findings are a direct result of adolescent-onset T2D.
背景
与健康同龄人相比，2型糖尿病（T2D）成人的灰质体积（GMV）显著更低。T2D青少年中是否存在GMV差异仍不清楚。因此，我们比较了患有T2D的肥胖青少年与年龄、种族和性别匹配的健康对照者之间的全脑和区域GMV。
方法
在一项横断面研究中，20名患有T2D的肥胖青少年接受了T1加权脑磁共振成像（MRI）检查。与20名年龄、种族和性别匹配的对照者进行比较。使用基于体素的形态学测量（VBM）确定两组之间全脑和区域GMV的差异。
结果
患有T2D的青少年的全脑GMV与颅内体积之比显著更低（T2D组为0.51±0.02，对照组为0.53±0.02，p = 0.02，Cohen's d = 0.85）。T2D组中有14个区域的GMV显著更低，其中9个位于颞叶或枕叶。T2D组中有6个区域的GMV增加。在进行多重比较校正后，所有区域差异在p<0.05时均具有统计学意义。
结论
这项初步研究的结果表明，与年龄、种族和性别匹配的同龄人相比，患有T2D的肥胖青少年的全脑GMV和区域GMV存在显著差异。需要进一步的研究来确定这些脑部发现是否是青少年期T2D的直接结果。
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