Department of Clinical and Molecular Medicine, Sapienza University, Policlinico Umberto I, Viale Regina Elena 324, 00161 Rome, Italy.
Laboratory of Biomedical Research, Niccolò Cusano University Foundation, Via Don Carlo Gnocchi 3, 00166 Rome, Italy.
Int J Mol Sci. 2018 Jan 26;19(2):379. doi: 10.3390/ijms19020379.
Galectin-3 (Gal-3) regulates basic cellular functions such as cell-cell and cell-matrix interactions, growth, proliferation, differentiation, and inflammation. It is not surprising, therefore, that this protein is involved in the pathogenesis of many relevant human diseases, including cancer, fibrosis, chronic inflammation and scarring affecting many different tissues. The papers published in the literature have progressively increased in number during the last decades, testifying the great interest given to this protein by numerous researchers involved in many different clinical contexts. Considering the crucial role exerted by Gal-3 in many different clinical conditions, Gal-3 is emerging as a new diagnostic, prognostic biomarker and as a new promising therapeutic target. The current review aims to extensively examine the studies published so far on the role of Gal-3 in all the clinical conditions and diseases, listed in alphabetical order, where it was analyzed.
半乳糖凝集素-3（Gal-3）调节基本的细胞功能，如细胞-细胞和细胞-基质相互作用、生长、增殖、分化和炎症。因此，毫不奇怪，这种蛋白质参与了许多相关人类疾病的发病机制，包括癌症、纤维化、慢性炎症和影响许多不同组织的瘢痕形成。过去几十年来，文献中发表的论文数量逐渐增加，证明了许多涉及许多不同临床环境的研究人员对这种蛋白质的极大兴趣。考虑到 Gal-3 在许多不同临床情况下发挥的关键作用，Gal-3 正在成为一种新的诊断、预后生物标志物和有前途的治疗靶点。本综述旨在广泛研究迄今为止在 Gal-3 在所有以字母顺序列出并进行了分析的临床情况和疾病中的作用的研究。
