γ-硫代三磷酸腺苷对犬胃平滑肌细胞膜的作用。
Effect of gamma-thio-ATP on dog stomach smooth muscle membranes.
作者信息
Grover A K, Oakes P
出版信息
Arch Int Pharmacodyn Ther. 1985 Dec;278(2):224-8.
PMID:2937378
Abstract
The effect of gamma-Thio-ATP on high affinity ATPase and on the ATP-dependent Ca-uptake of a plasma membrane fraction prepared from the dog stomach smooth muscle was examined. gamma-Thio-ATP did not act as a substrate for the ATP-dependent Ca-uptake and was only a poor substrate for the high affinity Ca-ATPase reaction. The compound, however, reversibly inhibited the uptake and the ATPase.
摘要
研究了γ-硫代三磷酸腺苷（gamma-Thio-ATP）对从犬胃平滑肌制备的质膜部分的高亲和力三磷酸腺苷酶（ATPase）以及对依赖ATP的钙摄取的影响。γ-硫代三磷酸腺苷并非依赖ATP的钙摄取的底物，且仅是高亲和力钙ATP酶反应的不良底物。然而，该化合物可逆地抑制了摄取和ATP酶。
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