血小板衍生生长因子受体α/人表皮生长因子受体2及血小板衍生生长因子受体α/p53在口腔鳞状细胞癌中的共表达

PDGFRα/HER2 and PDGFRα/p53 Co-expression in Oral Squamous Cell Carcinoma.

作者信息

Cierpikowski Piotr, Lis-Nawara Anna, Gajdzis Pawel, Bar Julia

机构信息

Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Wroclaw, Poland

Department of Immunopathology and Molecular Biology, Wroclaw Medical University, Wroclaw, Poland.

出版信息

Anticancer Res. 2018 Feb;38(2):795-802. doi: 10.21873/anticanres.12286.

DOI:10.21873/anticanres.12286

PMID:29374704

Abstract

AIM

The purpose of this study was to explore the parallel expression of platelet-derived growth factor receptor α (PDGFRα) and human epidermal growth factor receptor 2 (HER2) or p53 in relation to clinicopathological parameters of oral squamous cell carcinoma (OSCC) to define their role in progressive growth of tumor.

MATERIALS AND METHODS

Expression of PDGFRα, HER2 and p53 was evaluated in 71 OSCC samples by immunohistochemistry. HER2 status was verified by fluorescence in situ hybridization.

RESULTS

PDGFRα and p53 expression were associated with tumor grade (p=0.043 and p=0.040, respectively). HER2 expression was more frequent in advanced (III/IV) cancer (p=0.006). A positive correlation of PDGFRα with HER2 (r=0.267; p=0.024) and with p53 (r=0.266; p=0.025) was noted. PDGFRα/HER2 and PDGFRα/p53 co-expression was found more often in G3 than in G1 and G2 tumors (p=0.008 and p=0.015, respectively).

CONCLUSION

Our study revealed that PDGFRα/HER2 and PDGFRα/p53 co-expression exists in poorly differentiated OSCCs, suggesting that cooperation between these proteins might enhance aggressive behavior of tumor.

摘要

目的

本研究旨在探讨血小板衍生生长因子受体α（PDGFRα）与人类表皮生长因子受体2（HER2）或p53的平行表达与口腔鳞状细胞癌（OSCC）临床病理参数的关系，以确定它们在肿瘤进展生长中的作用。

材料与方法

采用免疫组织化学法评估71例OSCC样本中PDGFRα、HER2和p53的表达。通过荧光原位杂交验证HER2状态。

结果

PDGFRα和p53表达与肿瘤分级相关（分别为p = 0.043和p = 0.040）。HER2表达在晚期（III/IV期）癌症中更常见（p = 0.006）。观察到PDGFRα与HER2呈正相关（r = 0.267；p = 0.024），与p53呈正相关（r = 0.266；p = 0.025）。PDGFRα/HER2和PDGFRα/p53共表达在G3肿瘤中比在G1和G2肿瘤中更常见（分别为p = 0.008和p = 0.015）。