Department of Pathology, Ministry of Health Ankara Keçioren Training and Research Hospital, Ankara, Turkey.
Turk J Med Sci. 2014;44(3):411-6.
BACKGROUND/AIM: To investigate the expression of epidermal growth factor receptor-HER1 (EGFR), cerbB2 (HER2), p16, and p53, as well as the relationship of the expression of these genes with conventional parameters in squamous cell carcinoma (SCC) of the larynx.
Samples from 92 cases of diagnosed laryngeal SCC between 2001 and 2011 from the Pathology Department of Ministry of Health Ankara D1şkapi Yildirinm Beyazit Teaching & Research Hospital were studied by immunohistochemistry using EGFR, cerbB2, p16, and p53 antibodies.
An increase in the TNM stage and pathological tumor size status correlated with an increase in EGFR and cerbB2 expression. In the cases with lymphovascular invasion, the expression was detected at a higher ratio. Cases in which high levels ofpl6 and p53 expression were observed did not show any lymphovascular invasions.
Expressions of p53 and p16 were considered to be most effective in early carcinogenesis stages of laryngeal SCC. In comparison with p53 and p16 expression levels, EGFR and cerbB2 expression levels were observed to be associated with poor prognostic parameters and were higher at later stages of laryngeal carcinogenesis development.
背景/目的：研究表皮生长因子受体-HER1（EGFR）、cerbB2（HER2）、p16 和 p53 的表达，以及这些基因的表达与喉鳞状细胞癌（SCC）中常规参数的关系。
本研究采用免疫组织化学方法，使用 EGFR、cerbB2、p16 和 p53 抗体，对 2001 年至 2011 年期间卫生部安卡拉 D1şkapi Yildirim Beyazit 教学与研究医院病理科诊断为喉 SCC 的 92 例病例的样本进行了研究。
TNM 分期和病理肿瘤大小状态的增加与 EGFR 和 cerbB2 表达的增加相关。在有血管淋巴管侵犯的病例中，检测到更高比例的表达。高表达 p16 和 p53 的病例没有观察到任何血管淋巴管侵犯。
p53 和 p16 的表达被认为在喉 SCC 的早期癌变阶段最有效。与 p53 和 p16 的表达水平相比，EGFR 和 cerbB2 的表达水平与不良预后参数相关，并且在喉癌发生发展的晚期更高。
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