Post-Graduate Program in Movement Sciences, Sao Paulo State University-UNESP, Rio Claro, Brazil.
Exercise and Immunometabolism Research Group, Department of Physical Education, UNESP, Roberto Simonsen Street, 305, Presidente Prudente, 19060-900, Brazil.
Eur J Pediatr. 2018 Apr;177(4):551-558. doi: 10.1007/s00431-018-3101-6. Epub 2018 Jan 27.
We analyzed the effects of 1 year of engagement in ≥ 300 min/week of organized sports on inflammatory levels and vascular structure in adolescents. The sample was composed of 89 adolescents (11.6 ± 0.7 years old [43 boys and 46 girls]), stratified according to engagement in ≥ 300 min/week of sport practice during at least 12 months of follow-up (n = 15, sport practice; n = 74, non-sport practice). Arterial thickness (carotid and femoral) was assessed by ultrasound scan, while high sensitive C-reactive protein levels were used to assess inflammatory status. Trunk fatness (densitometry scanner), biological maturation (age at peak height velocity), blood pressure, and skipping breakfast were treated as covariates. Independently of body fatness and biological maturation, the group engaged in sports presented a higher reduction in C-reactive protein (mean difference -1.559 mg/L [95%CI -2.539 to -0.579]) than the non-sport group (mean difference -0.414 mg/L [95%CI -0.846 to 0.017]) (p = 0.040). There was a significant relationship between changes in C-reactive protein and changes in femoral intima-media thickness in the non-sport group (r = 0.311 [95%CI 0.026 to 0.549]).
Inflammation decreased in adolescents engaged in organized sports, independently of trunk fatness and biological maturation. Moreover, inflammation was related to arterial thickening only in adolescents not engaged in sports. What is Known: • Intima media thickness is a relevant marker of cardiovascular disease in pediatric groups, being affected by obesity and inflammation. • The importance of monitoring inflammatory markers from childhood is enhanced by the fact that alterations in these inflammatory markers in early life predict inflammation and alterations in carotid IMT in adulthood. What is New: • Anti-inflammatory properties related to physical exercise performed at moderate intensity, on inflammation and alterations in IMT are not clear in pediatric groups. • Due to the importance that sport participation has assumed as a promoter of improvements in health and quality of life, it is necessary to understand its potential benefits for cardiovascular health during human growth.
我们分析了青少年参与≥300 分钟/周的有组织运动 1 年后对炎症水平和血管结构的影响。该样本由 89 名青少年（11.6±0.7 岁[43 名男孩和 46 名女孩]）组成，根据至少 12 个月随访期间每周至少进行 300 分钟运动练习的情况进行分层（n=15，运动练习组；n=74，非运动练习组）。通过超声扫描评估动脉厚度（颈动脉和股动脉），同时使用高敏 C 反应蛋白水平评估炎症状态。躯干脂肪量（密度计扫描仪）、生物成熟度（身高快速增长期年龄）、血压和不吃早餐被视为协变量。独立于体脂和生物成熟度，运动组的 C 反应蛋白水平降低更明显（平均差异-1.559mg/L[95%CI-2.539 至-0.579]），而非运动组的 C 反应蛋白水平降低更明显（平均差异-0.414mg/L[95%CI-0.846 至 0.017]）（p=0.040）。非运动组 C 反应蛋白的变化与股动脉内中膜厚度的变化呈显著相关（r=0.311[95%CI0.026 至 0.549]）。
有组织运动可降低青少年的炎症水平，独立于躯干脂肪和生物成熟度。此外，在不参加运动的青少年中，炎症与动脉增厚有关。
• 内中膜厚度是儿科人群心血管疾病的一个相关标志物，受肥胖和炎症的影响。• 从儿童期开始监测这些炎症标志物的重要性在于，这些标志物在生命早期的变化可预测成年后炎症和颈动脉 IMT 的变化。
• 关于儿童群体中，进行中等强度的体育锻炼与炎症和 IMT 变化相关的抗炎特性尚不清楚。• 由于运动参与作为促进健康和生活质量提高的一种手段，其重要性已得到公认，因此有必要了解其对人类生长过程中心血管健康的潜在益处。
