Department of Urology, China Rehabilitation Research Centre, Rehabilitation School of Capital Medical University, Beijing, 100068, China.
Center of Neural Injury and Repair, Beijing Institute for Brain Disorders, Beijing, 100068, China.
World J Urol. 2018 May;36(5):829-836. doi: 10.1007/s00345-018-2198-6. Epub 2018 Jan 27.
To investigate the inhibitory effects of electrical stimulation of sacral dorsal root ganglion (DRG) on bladder activity under non-nociceptive and nociceptive bladder conditions in cats.
12 cats were divided into non-nociceptive and nociceptive groups. Saline was used to distend the bladder and induce non-nociceptive bladder activity, while acetic acid (AA, 0.25%) was used to induce nociceptive bladder overactivity, S1 or S2 DRG stimulation was applied via a pair of hook electrodes placed in the right S1 and S2 DRG.
In both non-nociceptive and nociceptive groups, stimulation at 3 and 5 Hz significantly increased bladder capacity (BC) and no significantly different between the two frequencies. In non-nociceptive group, S1 DRG stimulation at 3 Hz was as effective (increasing BC to 139.7 ± 5.6 and 166.9 ± 12.21% of control at 1T and 3/2T, respectively) as S2 DRG stimulation (increases BC to 129.2 ± 5.6 and 160.5 ± 13.3% of control). In nociceptive group, AA reduced the BC to 62.6 ± 11.7% of saline control. S1 DRG stimulation at 3 Hz was also as effective (increasing BC to 54.9 ± 5.5 and 61.9 ± 6.0% of saline control at 1T and 3/2T, respectively) as S2 DRG stimulation (increases BC to 58.3 ± 3.7 and 65.6 ± 3.7% of control).
This study showed the effective inhibition on bladder activity under both non-nociceptive and nociceptive conditions, suggesting the possibility of sacral DRG stimulation to treat bladder overactivity.
研究骶神经根节（DRG）电刺激在非伤害性和伤害性膀胱条件下对猫膀胱活动的抑制作用。
将 12 只猫分为非伤害性和伤害性两组。用生理盐水扩张膀胱，诱导非伤害性膀胱活动，用 0.25%乙酸（AA）诱导伤害性膀胱过度活动，用一对钩状电极放置在右侧 S1 和 S2 DRG 上进行 S1 或 S2 DRG 刺激。
在非伤害性和伤害性两组中，3Hz 和 5Hz 刺激均显著增加膀胱容量（BC），且两种频率之间无显著差异。在非伤害性组中，S1 DRG 刺激 3Hz 与 S2 DRG 刺激（分别将 BC 增加至对照的 139.7±5.6%和 166.9±12.21%）同样有效（将 BC 增加至对照的 129.2±5.6%和 160.5±13.3%）。在伤害性组中，AA 将 BC 降低至盐水对照的 62.6±11.7%。S1 DRG 刺激 3Hz 与 S2 DRG 刺激同样有效（将 BC 分别增加至盐水对照的 54.9±5.5%和 61.9±6.0%）（将 BC 分别增加至盐水对照的 58.3±3.7%和 65.6±3.7%）。
本研究表明，在非伤害性和伤害性条件下，均能有效抑制膀胱活动，提示骶神经根节刺激治疗膀胱过度活动的可能性。
