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[多囊卵巢综合征患者冻融胚胎移植后的妊娠结局分析]

[Analysis of pregnancy outcomes of polycystic ovary syndrome patients after frozen embryo transfer].

作者信息

Lyu X D, Qiao J

机构信息

Center of Reproductive Medicine, Peking University Third Hospital, Beijing 100191, China.

出版信息

Zhonghua Fu Chan Ke Za Zhi. 2018 Jan 25;53(1):31-34. doi: 10.3760/cma.j.issn.0529-567X.2018.01.007.

Abstract

To investigate pregnancy outcomes of the patients with polycystic ovary syndrome (PCOS) after frozen embryo transfer (FET) . Data of 2 367 PCOS patients received in vitro fertilization-embryo transfer [including fresh embryo transfer (fET) and FET] from January 2009 to December 2015 in Peking University Third Hospital were evaluated retrospectively. The basal characteristics, pregnancy complications and outcomes were analyzed, then identified the relative factors followed. Totally 2 367 patients received in vitro fertilization-embryo transfer: 1 106 were treated with fET, and the rest 1 261 cases were treated with FET. The incidence of gestational diabetes mellitus (GDM) was lower in FET group [4.04%(51/1 261) versus 6.15%(68/1 106)], the difference was statistically significant (0.05). Singletons born after FET had higher birth weight than fET [(3 406±548) versus (3 360±533) g], the difference was statistically significant (0.05). There was no difference of other pregnancy complications between the two groups (all 0.05). fET was an independent risk factor for GDM (adjusted 1.570, 95% 1.075-2.294). Compared with fET, FET could decrease the risk of GDM and receive better neonatal outcomes in patients with PCOS.

摘要

探讨多囊卵巢综合征(PCOS)患者冻融胚胎移植(FET)后的妊娠结局。回顾性分析2009年1月至2015年12月在北京大学第三医院接受体外受精 - 胚胎移植(包括新鲜胚胎移植和FET)的2367例PCOS患者的数据。分析基础特征、妊娠并发症及结局,然后确定相关因素。共有2367例患者接受体外受精 - 胚胎移植:1106例接受新鲜胚胎移植,其余1261例接受FET。FET组妊娠糖尿病(GDM)发生率较低[4.04%(51/1261)对6.15%(68/1106)],差异有统计学意义(0.05)。FET后出生的单胎出生体重高于新鲜胚胎移植组[(3406±548)对(3360±533)g],差异有统计学意义(0.0 < 0.05)。两组间其他妊娠并发症无差异(均0.05)。新鲜胚胎移植是GDM的独立危险因素(校正后1.570,95% 1.075 - 2.294)。与新鲜胚胎移植相比,FET可降低PCOS患者GDM风险并获得更好的新生儿结局。

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